Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: A facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy

Chih Wei Lai; Yu Hsiu Wang; Cheng Hsuan Lai; Meng Ju Yang; Chun Yen Chen; Pi Tai Chou; Chi Shun Chan; Yun Chi; Yu Chun Chen; Jong Kai Hsiao

doi:10.1002/smll.200700283

Iridium-complex-functionalized Fe₃O₄/SiO₂ core/shell nanoparticles: A facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy

Chih Wei Lai, Yu Hsiu Wang, Cheng Hsuan Lai, Meng Ju Yang, Chun Yen Chen, Pi Tai Chou, Chi Shun Chan, Yun Chi, Yu Chun Chen, Jong Kai Hsiao

Research output: Contribution to journal › Article › peer-review

231 Scopus citations

Abstract

Highly uniform Fe₃O₄/SiO₂ core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe₃O₄/SiO ₂ (Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spinorbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.

Original language	English (US)
Pages (from-to)	218-224
Number of pages	7
Journal	Small
Volume	4
Issue number	2
DOIs	https://doi.org/10.1002/smll.200700283
State	Published - Feb 2008
Externally published	Yes

Keywords

Biomateriate
Imaging
Iridium
Photodynamic therapy
Silicates

ASJC Scopus subject areas

General Chemistry
Engineering (miscellaneous)
Biotechnology
General Materials Science
Biomaterials

Access to Document

10.1002/smll.200700283

Cite this

Lai, C. W., Wang, Y. H., Lai, C. H., Yang, M. J., Chen, C. Y., Chou, P. T., Chan, C. S., Chi, Y., Chen, Y. C., & Hsiao, J. K. (2008). Iridium-complex-functionalized Fe₃O₄/SiO₂ core/shell nanoparticles: A facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy. Small, 4(2), 218-224. https://doi.org/10.1002/smll.200700283

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abstract = "Highly uniform Fe3O4/SiO2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe3O4/SiO 2 (Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spinorbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.",

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AU - Chou, Pi Tai

AU - Chan, Chi Shun

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