Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: A facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy

Chih Wei Lai, Yu Hsiu Wang, Cheng Hsuan Lai, Meng Ju Yang, Chun Yen Chen, Pi Tai Chou, Chi Shun Chan, Yun Chi, Yu Chun Chen, Jong Kai Hsiao

Research output: Contribution to journalArticle

Abstract

Highly uniform Fe3O4/SiO2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe3O4/SiO 2 (Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spinorbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalSmall
Volume4
Issue number2
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

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Keywords

  • Biomateriate
  • Imaging
  • Iridium
  • Photodynamic therapy
  • Silicates

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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