Iron exacerbates aniline-associated splenic toxicity

M Khan, Xiaohong Wu, Nancy W. Alcock, Paul J. Boor, Ghulam Ansari

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Our earlier studies have shown that aniline exposure in rats causes time- and dose-dependent accumulation of iron in the spleen, which may exacerbate aniline splenotoxicity by catalyzing free-radical reactions. The present studies were conducted to test whether aniline-induced splenic toxicity could be potentiated by iron overload. For 30 d male Sprague-Dawley rats received the following treatments: 0.5 mmol/kg/d aniline hydrochloride (AH) by gavage (AH group); 3% carbonyl iron-supplemented diet (IR group); 0.5 mmol/kg/d AH by gavage and iron-supplemented diet (AH + IR group); or no treatments (controls). Treatment-related significant increases in total iron, low molecular weight chelatable iron, lipid peroxidation, and protein oxidation were observed in the spleens of all the groups compared to control. However, these changes were much greater in the combined AH + IR group. The aniline-induced morphological changes in the spleen were consistent with out earlier observations, but were more pronounced in the AH + IR group. The increased toxicity, as evident from greater oxidative stress and morphological changes in the AH + IR group, suggests that iron potentiates the splenic toxicity of aniline.

Original languageEnglish (US)
Pages (from-to)173-184
Number of pages12
JournalJournal of Toxicology and Environmental Health - Part A
Volume57
Issue number3
StatePublished - Jun 11 1999

Fingerprint

Aniline
Toxicity
Iron
toxicity
iron
diet
Spleen
Nutrition
free radical
aniline
Rats
Free radical reactions
Diet
lipid
Iron Overload
Oxidative stress
oxidation
protein
Lipids
Lipid Peroxidation

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Iron exacerbates aniline-associated splenic toxicity. / Khan, M; Wu, Xiaohong; Alcock, Nancy W.; Boor, Paul J.; Ansari, Ghulam.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 57, No. 3, 11.06.1999, p. 173-184.

Research output: Contribution to journalArticle

Khan, M ; Wu, Xiaohong ; Alcock, Nancy W. ; Boor, Paul J. ; Ansari, Ghulam. / Iron exacerbates aniline-associated splenic toxicity. In: Journal of Toxicology and Environmental Health - Part A. 1999 ; Vol. 57, No. 3. pp. 173-184.
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