Is maternal serum heat stable alkaline phosphatase an index of fetal maturity?

Eugene Okpere, Anthony Okorodudu, Osahan Gbinigie, C. Lackman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A cross sectional estimation of serum heat stable alkaline phosphatase (HSAP) levels in 145 women with uncomplicated pregnancies between 24-41 weeks gestation showed increasing levels with advancing gestation and a steep rise at about 34 weeks gestation from a mean level of 17.3±6.5 μg/ml to a mean level of 36.1±1.5 μg/ml (t = 7.4 p < .001) at about 37 weeks gestation. Ninety-three point seven percent (93.7%) and 24.4% of women between 31-35 weeks gestation and 27-34 weeks gestation respectively had levels equal to or exceeding 20 μg/ml. It is postulated that serum HSAP represent stages of fetal maturity rather than gestational age per se and that there is a possible relationship between serum HSAP and amniotic fluid lecithin viewed against a background of a similar rise of amniotic fluid lecithin levels at about 33 weeks gestation and the common role of steroid receptor sites in the formation of both HSAP and Lecithin.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalMedical Hypotheses
Volume21
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

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Alkaline Phosphatase
Hot Temperature
Mothers
Pregnancy
Serum
Lecithins
Amniotic Fluid
Steroid Receptors
Gestational Age

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Is maternal serum heat stable alkaline phosphatase an index of fetal maturity? / Okpere, Eugene; Okorodudu, Anthony; Gbinigie, Osahan; Lackman, C.

In: Medical Hypotheses, Vol. 21, No. 2, 1986, p. 225-230.

Research output: Contribution to journalArticle

Okpere, Eugene ; Okorodudu, Anthony ; Gbinigie, Osahan ; Lackman, C. / Is maternal serum heat stable alkaline phosphatase an index of fetal maturity?. In: Medical Hypotheses. 1986 ; Vol. 21, No. 2. pp. 225-230.
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