Is maternal serum heat stable alkaline phosphatase an index of fetal maturity?

Eugene Okpere, A. Okorodudu, Osahan Gbinigie, C. Lackman

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1 Scopus citations


A cross sectional estimation of serum heat stable alkaline phosphatase (HSAP) levels in 145 women with uncomplicated pregnancies between 24-41 weeks gestation showed increasing levels with advancing gestation and a steep rise at about 34 weeks gestation from a mean level of 17.3±6.5 μg/ml to a mean level of 36.1±1.5 μg/ml (t = 7.4 p < .001) at about 37 weeks gestation. Ninety-three point seven percent (93.7%) and 24.4% of women between 31-35 weeks gestation and 27-34 weeks gestation respectively had levels equal to or exceeding 20 μg/ml. It is postulated that serum HSAP represent stages of fetal maturity rather than gestational age per se and that there is a possible relationship between serum HSAP and amniotic fluid lecithin viewed against a background of a similar rise of amniotic fluid lecithin levels at about 33 weeks gestation and the common role of steroid receptor sites in the formation of both HSAP and Lecithin.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalMedical Hypotheses
Issue number2
StatePublished - Oct 1986
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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