Is nodding syndrome in northern Uganda linked to consumption of mycotoxin contaminated food grains?

Richard Echodu, Hilary Edema, Geoffrey Maxwell Malinga, Adam Hendy, Robert Colebunders, Joyce Moriku Kaducu, Emilio Ovuga, Geert Haesaert

Research output: Contribution to journalArticle

Abstract

Objective: Nodding syndrome (NS) is a type of epilepsy characterized by repeated head-nodding seizures that appear in previously healthy children between 3 and 18 years of age. In 2012, during a WHO International Meeting on NS in Kampala, Uganda, it was recommended that fungal contamination of foods should be investigated as a possible cause of the disease. We therefore aimed to assess whether consumption of fungal mycotoxins contributes to NS development. Results: We detected similar high levels of total aflatoxin and ochratoxin in mostly millet, sorghum, maize and groundnuts in both households with and without children with NS. Furthermore, there was no significant association between concentrations of total aflatoxin, ochratoxin and doxynivalenol and the presence of children with NS in households. In conclusion, our results show no supporting evidence for the association of NS with consumption of mycotoxins in contaminated foods.

Original languageEnglish (US)
Article number678
JournalBMC Research Notes
Volume11
Issue number1
DOIs
StatePublished - Sep 24 2018

Fingerprint

Nodding Syndrome
Ochratoxins
Aflatoxins
Uganda
Mycotoxins
Food
Contamination
Food Contamination
Sorghum
Zea mays
Epilepsy
Seizures
Head

Keywords

  • Food grain
  • Mycotoxin
  • Nodding syndrome
  • Uganda

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Echodu, R., Edema, H., Malinga, G. M., Hendy, A., Colebunders, R., Moriku Kaducu, J., ... Haesaert, G. (2018). Is nodding syndrome in northern Uganda linked to consumption of mycotoxin contaminated food grains? BMC Research Notes, 11(1), [678]. https://doi.org/10.1186/s13104-018-3774-y

Is nodding syndrome in northern Uganda linked to consumption of mycotoxin contaminated food grains? / Echodu, Richard; Edema, Hilary; Malinga, Geoffrey Maxwell; Hendy, Adam; Colebunders, Robert; Moriku Kaducu, Joyce; Ovuga, Emilio; Haesaert, Geert.

In: BMC Research Notes, Vol. 11, No. 1, 678, 24.09.2018.

Research output: Contribution to journalArticle

Echodu, R, Edema, H, Malinga, GM, Hendy, A, Colebunders, R, Moriku Kaducu, J, Ovuga, E & Haesaert, G 2018, 'Is nodding syndrome in northern Uganda linked to consumption of mycotoxin contaminated food grains?', BMC Research Notes, vol. 11, no. 1, 678. https://doi.org/10.1186/s13104-018-3774-y
Echodu, Richard ; Edema, Hilary ; Malinga, Geoffrey Maxwell ; Hendy, Adam ; Colebunders, Robert ; Moriku Kaducu, Joyce ; Ovuga, Emilio ; Haesaert, Geert. / Is nodding syndrome in northern Uganda linked to consumption of mycotoxin contaminated food grains?. In: BMC Research Notes. 2018 ; Vol. 11, No. 1.
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