TY - JOUR
T1 - Is obesity-induced ECM remodeling a prelude to the development of various diseases?
AU - Rahimi, Azam
AU - Rasouli, Mehdi
AU - Heidari keshel, Saeed
AU - Ebrahimi, Maryam
AU - Pakdel, Farzad
N1 - Publisher Copyright:
© 2023 Asia Oceania Association for the Study of Obesity
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Due to the increasing incidence rate of obesity worldwide and the associated complications such as type 2 diabetes and cardiovascular diseases, research on the adipose tissue physiology and the role of the extracellular matrix (ECM) has gained tremendous attention. The ECM, one of the most crucial components in body tissues, undergoes remodeling and regeneration of its constituents to guarantee normal tissue function. There is a crosstalk between fat tissue and various body organs, including but not limited to the liver, heart, kidney, skeletal muscle, and so forth. These organs respond to fat tissue signals through changes in ECM, function, and their secretory products. Obesity can cause ECM remodeling, inflammation, fibrosis, insulin resistance, and disrupted metabolism in different organs. However, the mechanisms underlying the reciprocal communication between various organs during obesity are still not fully elucidated. Gaining a profound knowledge of ECM alterations during the progression of obesity will pave the way toward developing potential strategies to either circumvent pathological conditions or open an avenue to treat complications associated with obesity.
AB - Due to the increasing incidence rate of obesity worldwide and the associated complications such as type 2 diabetes and cardiovascular diseases, research on the adipose tissue physiology and the role of the extracellular matrix (ECM) has gained tremendous attention. The ECM, one of the most crucial components in body tissues, undergoes remodeling and regeneration of its constituents to guarantee normal tissue function. There is a crosstalk between fat tissue and various body organs, including but not limited to the liver, heart, kidney, skeletal muscle, and so forth. These organs respond to fat tissue signals through changes in ECM, function, and their secretory products. Obesity can cause ECM remodeling, inflammation, fibrosis, insulin resistance, and disrupted metabolism in different organs. However, the mechanisms underlying the reciprocal communication between various organs during obesity are still not fully elucidated. Gaining a profound knowledge of ECM alterations during the progression of obesity will pave the way toward developing potential strategies to either circumvent pathological conditions or open an avenue to treat complications associated with obesity.
KW - Extracellular matrix
KW - Insulin resistance
KW - Obesity
KW - Organ crosstalk
KW - Organ dysfunction
KW - Remodeling
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U2 - 10.1016/j.orcp.2023.02.002
DO - 10.1016/j.orcp.2023.02.002
M3 - Review article
C2 - 36863919
AN - SCOPUS:85150412932
SN - 1871-403X
VL - 17
SP - 95
EP - 101
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 2
ER -