Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?

Bárbara Aparecida Chaves; Denise Anete Madureira de Alvarenga; Matheus de Oliveira Costa Pereira; Marcelo Gordo; Emanuelle L. Da Silva; Edson Rodrigues Costa; Aline Souza de Menezes Medeiros; Igor José Martins Pedrosa; Daniela Brito; Maurício Teixeira Lima; Maria Paula Mourão; Wuelton M. Monteiro; Nikos Vasilakis; Cristiana Ferreira Alves de Brito; Gisely C. Melo; Marcus V.G. Lacerda

doi:10.1186/s12936-022-04349-6

Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?

Bárbara Aparecida Chaves, Denise Anete Madureira de Alvarenga, Matheus de Oliveira Costa Pereira, Marcelo Gordo, Emanuelle L. Da Silva, Edson Rodrigues Costa, Aline Souza de Menezes Medeiros, Igor José Martins Pedrosa, Daniela Brito, Maurício Teixeira Lima, Maria Paula Mourão, Wuelton M. Monteiro, Nikos Vasilakis, Cristiana Ferreira Alves de Brito, Gisely C. Melo, Marcus V.G. Lacerda

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The groundwork for malaria elimination does not currently consider the potential of Plasmodium zoonotic cycles that involve non-human primates (NHPs) in sylvatic environments. Since vivax malaria is less responsive to control measures, finding Plasmodium vivax infected NHPs adds even more concern. Methods: Both Free-living monkeys in forest fragments inside the urban area and captive monkeys from a local zoo had blood samples tested for Plasmodium species. Results: In this study, among the Neotropical monkeys tested, three (4.4%), one captive and two free-living, were found to be naturally infected by P. vivax. Conclusion: This important finding indicates that it is necessary to estimate the extent to which P. vivax NHP infection contributes to the maintenance of malaria transmission to humans. Therefore, the discussion on wildlife conservation and management must be incorporated into the malaria elimination agenda.

Original language	English (US)
Article number	343
Journal	Malaria Journal
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12936-022-04349-6
State	Published - Dec 2022

Keywords

Malaria
Malaria elimination
Non-human primates
Plasmodium vivax
Zoonotic cycle

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1186/s12936-022-04349-6

Cite this

Chaves, B. A., de Alvarenga, D. A. M., Pereira, M. D. O. C., Gordo, M., Da Silva, E. L., Costa, E. R., Medeiros, A. S. D. M., Pedrosa, I. J. M., Brito, D., Lima, M. T., Mourão, M. P., Monteiro, W. M., Vasilakis, N., de Brito, C. F. A., Melo, G. C., & Lacerda, M. V. G. (2022). Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination? Malaria Journal, 21(1), [343]. https://doi.org/10.1186/s12936-022-04349-6

Chaves, BA, de Alvarenga, DAM, Pereira, MDOC, Gordo, M, Da Silva, EL, Costa, ER, Medeiros, ASDM, Pedrosa, IJM, Brito, D, Lima, MT, Mourão, MP, Monteiro, WM, Vasilakis, N, de Brito, CFA, Melo, GC & Lacerda, MVG 2022, 'Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?', Malaria Journal, vol. 21, no. 1, 343. https://doi.org/10.1186/s12936-022-04349-6

@article{a1322ca462e64c97bbedd66e9066fa2e,

title = "Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?",

abstract = "Background: The groundwork for malaria elimination does not currently consider the potential of Plasmodium zoonotic cycles that involve non-human primates (NHPs) in sylvatic environments. Since vivax malaria is less responsive to control measures, finding Plasmodium vivax infected NHPs adds even more concern. Methods: Both Free-living monkeys in forest fragments inside the urban area and captive monkeys from a local zoo had blood samples tested for Plasmodium species. Results: In this study, among the Neotropical monkeys tested, three (4.4%), one captive and two free-living, were found to be naturally infected by P. vivax. Conclusion: This important finding indicates that it is necessary to estimate the extent to which P. vivax NHP infection contributes to the maintenance of malaria transmission to humans. Therefore, the discussion on wildlife conservation and management must be incorporated into the malaria elimination agenda.",

keywords = "Malaria, Malaria elimination, Non-human primates, Plasmodium vivax, Zoonotic cycle",

author = "Chaves, {B{\'a}rbara Aparecida} and {de Alvarenga}, {Denise Anete Madureira} and Pereira, {Matheus de Oliveira Costa} and Marcelo Gordo and {Da Silva}, {Emanuelle L.} and Costa, {Edson Rodrigues} and Medeiros, {Aline Souza de Menezes} and Pedrosa, {Igor Jos{\'e} Martins} and Daniela Brito and Lima, {Maur{\'i}cio Teixeira} and Mour{\~a}o, {Maria Paula} and Monteiro, {Wuelton M.} and Nikos Vasilakis and {de Brito}, {Cristiana Ferreira Alves} and Melo, {Gisely C.} and Lacerda, {Marcus V.G.}",

note = "Funding Information: The authors would like to thank Centro de Instru{\c c}{\~a}o de Guerra na Selva (CIGs) for their support in NHP collections. Funding Information: This research was funded by an International Collaborations in Infectious Disease Research (ICIDR) grant, U01 AI115577, which was awarded to NV by the National Institutes of Health and by Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Amazonas—via Call No. 006/2019 - UNIVERSAL AMAZONAS. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s12936-022-04349-6",

language = "English (US)",

volume = "21",

journal = "Malaria Journal",

issn = "1475-2875",