Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency

Manasa Reddy, Bernard Tawfik, Chakri Gavva, Sean Yates, Nicole De Simone, Sandra L. Hofmann, Siayareh Rambally, Ravi Sarode

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Thrombosis is known to occur in patients with rare inherited bleeding disorders, usually in the presence of a thrombotic risk factor such as surgery and/or factor replacement therapy, but sometimes spontaneously. We present the case of a 72-year-old African American male diagnosed with congenital factor VII (FVII) deficiency after presenting with ischemic stroke, presumably embolic, in the setting of atherosclerotic carotid artery stenosis. The patient had an international normalized ratio (INR) of 2.0 at presentation, with FVII activity of 6% and normal Extem clotting time in rotational thromboelastometry. He was treated with aspirin (325 mg daily) and clopidogrel (75 mg daily) with no additional bleeding or thrombotic complications throughout his admission. This case provides further evidence that moderate to severe FVII deficiency does not protect against thrombosis.

Original languageEnglish (US)
Pages (from-to)364-367
Number of pages4
JournalTransfusion and Apheresis Science
Volume55
Issue number3
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Factor VII Deficiency
clopidogrel
Thrombosis
Stroke
Hemorrhage
Thrombelastography
Factor VII
International Normalized Ratio
Carotid Stenosis
African Americans
Aspirin
Therapeutics

Keywords

  • Factor VII deficiency
  • Stroke
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

Cite this

Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency. / Reddy, Manasa; Tawfik, Bernard; Gavva, Chakri; Yates, Sean; De Simone, Nicole; Hofmann, Sandra L.; Rambally, Siayareh; Sarode, Ravi.

In: Transfusion and Apheresis Science, Vol. 55, No. 3, 01.12.2016, p. 364-367.

Research output: Contribution to journalArticle

Reddy, M, Tawfik, B, Gavva, C, Yates, S, De Simone, N, Hofmann, SL, Rambally, S & Sarode, R 2016, 'Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency', Transfusion and Apheresis Science, vol. 55, no. 3, pp. 364-367. https://doi.org/10.1016/j.transci.2016.10.002
Reddy, Manasa ; Tawfik, Bernard ; Gavva, Chakri ; Yates, Sean ; De Simone, Nicole ; Hofmann, Sandra L. ; Rambally, Siayareh ; Sarode, Ravi. / Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency. In: Transfusion and Apheresis Science. 2016 ; Vol. 55, No. 3. pp. 364-367.
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