Japanese encephalitis and Japanese encephalitis virus in mainland China

Yayun Zheng, Minghua Li, Huanyu Wang, Guodong Liang

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations


Japanese encephalitis (JE), caused by Japanese encephalitis virus (JEV) infection, is the most important viral encephalitis in the world. Approximately 35,000-50,000 people suffer from JE every year, with a mortality rate of 10,000-15,000 people per year. Although the safety and efficacy of JE vaccines (inactivated and attenuated) have been demonstrated, China still accounts for 50% of the reported JE cases worldwide. In this review, we provide information about the burden of JE in mainland China and the corresponding epidemiology from 1949 to 2010, including the morbidity and mortality of JE; the age, gender, and vocational distribution of JE cases; its regional and seasonal distribution; and JE immunization. In addition, we discuss the relationships among vectors, hosts, and JEV isolates from mainland China; the dominant vector species for JEV transmission; the variety of JEV genotypes and the different biological characteristics of the different JEV genotypes; and the molecular evolution of JEV.

Original languageEnglish (US)
Pages (from-to)301-322
Number of pages22
JournalReviews in Medical Virology
Issue number5
StatePublished - Sep 2012
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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