Jatobal virus is a reassortant containing the small RNA of Oropouche virus

M. F. Saeed, H. Wang, M. Suderman, D. W C Beasley, A. Travassos da Rosa, L. Li, R. E. Shope, R. B. Tesh, A. D T Barrett

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Abstract

Jatobal (JAT) virus was isolated in 1985 from a carnivore (Nasua nasua) in Tucuruí, Pará state, Brazil and was classified as a distinct member of the Simbu serogroup of the Bunyavirus genus, family Bunyaviridae on the basis of neutralization tests. On the basis of nucleotide sequencing, we have found that the small (S) RNA of JAT virus is very similar ( > 95% identity) to that of Oropouche (ORO) virus, in particular, the Peruvian genotype of ORO virus. In comparison, limited nucleotide sequencing of the G2 protein gene, encoded by the middle (M) RNA, of JAT and ORO viruses, revealed relatively little identity ( < 66%) between these two viruses. Neutralization tests confirmed the lack of cross-reactivity between the viruses. These results suggest that JAT virus is a reassortant containing the S RNA of ORO virus. JAT virus was attenuated in hamsters compared to ORO virus suggesting that the S RNA of ORO virus is not directly involved in hamster virulence.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalVirus Research
Volume77
Issue number1
DOIs
StatePublished - 2001

Fingerprint

RNA Viruses
Viruses
Procyonidae
Neutralization Tests
Cricetinae
Nucleotides
Orthobunyavirus
Bunyaviridae
Protein Sequence Analysis
Brazil
Virulence
Genotype
RNA

Keywords

  • Jabotal virus
  • RNA
  • Virus

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

Cite this

Jatobal virus is a reassortant containing the small RNA of Oropouche virus. / Saeed, M. F.; Wang, H.; Suderman, M.; Beasley, D. W C; Travassos da Rosa, A.; Li, L.; Shope, R. E.; Tesh, R. B.; Barrett, A. D T.

In: Virus Research, Vol. 77, No. 1, 2001, p. 25-30.

Research output: Contribution to journalArticle

Saeed, MF, Wang, H, Suderman, M, Beasley, DWC, Travassos da Rosa, A, Li, L, Shope, RE, Tesh, RB & Barrett, ADT 2001, 'Jatobal virus is a reassortant containing the small RNA of Oropouche virus', Virus Research, vol. 77, no. 1, pp. 25-30. https://doi.org/10.1016/S0168-1702(01)00262-3
Saeed, M. F. ; Wang, H. ; Suderman, M. ; Beasley, D. W C ; Travassos da Rosa, A. ; Li, L. ; Shope, R. E. ; Tesh, R. B. ; Barrett, A. D T. / Jatobal virus is a reassortant containing the small RNA of Oropouche virus. In: Virus Research. 2001 ; Vol. 77, No. 1. pp. 25-30.
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