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JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both in Vitro and in Vivo
Zhong Li
, Jimin Xu
, Yuekun Lang
, Xiaoyu Fan
, Lili Kuo
, Lianna D'Brant
, Saiyang Hu
, Subodh Kumar Samrat
, Nicole Trudeau
, Anil M. Tharappel
, Natasha Rugenstein
, Cheri A. Koetzner
, Jing Zhang
, Haiying Chen
, Laura D. Kramer
, David Butler
, Qing Yu Zhang
,
Jia Zhou
, Hongmin Li
Pharmacology & Toxicology
Research output
:
Contribution to journal
›
Article
›
peer-review
43
Scopus citations
Overview
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Keyphrases
Antiviral Assay
33%
Antiviral Efficacy
33%
Brain Organoids
33%
Broad-spectrum Inhibitor
33%
Cell-based
33%
Effective Therapy
33%
Flavivirus
66%
Human Disease
33%
Improved Efficacy
66%
Improved Pharmacokinetics
100%
Minibrain
33%
Molecular Interactions
33%
Neural Stem Cells
33%
New Analogs
33%
Niclosamide
33%
Niclosamide Derivatives
100%
NS2B
66%
Pharmacokinetic Properties
33%
Pluripotent
33%
Recent Outbreaks
33%
Small Molecule Libraries
33%
Viral Protease
66%
Viremia
33%
Virus
33%
Zika Virus
100%
Zika Virus Infection
100%
Pharmacology, Toxicology and Pharmaceutical Science
Antivirus Agent
50%
Diseases
25%
Flavivirus
50%
Niclosamide
100%
Pharmacokinetics
100%
Proteinase
50%
Viremia
25%
Zika Fever
100%
Zika Virus
75%