Junín virus pathogenesis and virus replication

Ashley Grant, Alexey Seregin, Cheng Huang, Olga Kolokoltsova, Allan Brasier, Clarence Peters, Slobodan Paessler

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.

Original languageEnglish (US)
Pages (from-to)2317-2339
Number of pages23
JournalViruses
Volume4
Issue number10
DOIs
StatePublished - Oct 2012

Fingerprint

Virus Replication
Viruses
Reverse Genetics
Argentina
Adaptive Immunity
Innate Immunity
Molecular Biology
Rodentia
Fever
Vaccines
Animal Models
Technology
Morbidity
Mortality
Infection
Research

Keywords

  • Arenavirus
  • Junín virus
  • Pathogenesis

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Grant, A., Seregin, A., Huang, C., Kolokoltsova, O., Brasier, A., Peters, C., & Paessler, S. (2012). Junín virus pathogenesis and virus replication. Viruses, 4(10), 2317-2339. https://doi.org/10.3390/v4102317

Junín virus pathogenesis and virus replication. / Grant, Ashley; Seregin, Alexey; Huang, Cheng; Kolokoltsova, Olga; Brasier, Allan; Peters, Clarence; Paessler, Slobodan.

In: Viruses, Vol. 4, No. 10, 10.2012, p. 2317-2339.

Research output: Contribution to journalArticle

Grant, A, Seregin, A, Huang, C, Kolokoltsova, O, Brasier, A, Peters, C & Paessler, S 2012, 'Junín virus pathogenesis and virus replication', Viruses, vol. 4, no. 10, pp. 2317-2339. https://doi.org/10.3390/v4102317
Grant A, Seregin A, Huang C, Kolokoltsova O, Brasier A, Peters C et al. Junín virus pathogenesis and virus replication. Viruses. 2012 Oct;4(10):2317-2339. https://doi.org/10.3390/v4102317
Grant, Ashley ; Seregin, Alexey ; Huang, Cheng ; Kolokoltsova, Olga ; Brasier, Allan ; Peters, Clarence ; Paessler, Slobodan. / Junín virus pathogenesis and virus replication. In: Viruses. 2012 ; Vol. 4, No. 10. pp. 2317-2339.
@article{bec8848a01bf481ba8414fa3a9cc11f7,
title = "Jun{\'i}n virus pathogenesis and virus replication",
abstract = "Jun{\'i}n virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Jun{\'i}n virus. We will review the pathogenesis of Jun{\'i}n virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Jun{\'i}n virus in elucidating virus attenuation. We will also summarize current knowledge on Jun{\'i}n virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.",
keywords = "Arenavirus, Jun{\'i}n virus, Pathogenesis",
author = "Ashley Grant and Alexey Seregin and Cheng Huang and Olga Kolokoltsova and Allan Brasier and Clarence Peters and Slobodan Paessler",
year = "2012",
month = "10",
doi = "10.3390/v4102317",
language = "English (US)",
volume = "4",
pages = "2317--2339",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",

}

TY - JOUR

T1 - Junín virus pathogenesis and virus replication

AU - Grant, Ashley

AU - Seregin, Alexey

AU - Huang, Cheng

AU - Kolokoltsova, Olga

AU - Brasier, Allan

AU - Peters, Clarence

AU - Paessler, Slobodan

PY - 2012/10

Y1 - 2012/10

N2 - Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.

AB - Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.

KW - Arenavirus

KW - Junín virus

KW - Pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=84868127075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868127075&partnerID=8YFLogxK

U2 - 10.3390/v4102317

DO - 10.3390/v4102317

M3 - Article

VL - 4

SP - 2317

EP - 2339

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 10

ER -