Junín virus pathogenesis and virus replication

Ashley Grant, Alexey Seregin, Cheng Huang, Olga Kolokoltsova, Allan Brasier, Clarence Peters, Slobodan Paessler

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.

Original languageEnglish (US)
Pages (from-to)2317-2339
Number of pages23
JournalViruses
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2012

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Keywords

  • Arenavirus
  • Junín virus
  • Pathogenesis

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Grant, A., Seregin, A., Huang, C., Kolokoltsova, O., Brasier, A., Peters, C., & Paessler, S. (2012). Junín virus pathogenesis and virus replication. Viruses, 4(10), 2317-2339. https://doi.org/10.3390/v4102317