Abstract
Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species. Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodonazarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 589-597 |
| Number of pages | 9 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 44 |
| Issue number | 6 |
| State | Published - 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
Cite this
Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. / Mills, J. N.; Ellis, B. A.; McKee, K. T.; Ksiazek, Thomas; Oro, J. G B; Maiztegui, J. I.; Calderon, G. E.; Peters, C. J.; Childs, J. E.
In: American Journal of Tropical Medicine and Hygiene, Vol. 44, No. 6, 1991, p. 589-597.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Junin virus activity in rodents from endemic and nonendemic loci in central Argentina
AU - Mills, J. N.
AU - Ellis, B. A.
AU - McKee, K. T.
AU - Ksiazek, Thomas
AU - Oro, J. G B
AU - Maiztegui, J. I.
AU - Calderon, G. E.
AU - Peters, C. J.
AU - Childs, J. E.
PY - 1991
Y1 - 1991
N2 - Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species. Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodonazarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward.
AB - Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species. Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodonazarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward.
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M3 - Article
C2 - 1650148
AN - SCOPUS:0026329042
VL - 44
SP - 589
EP - 597
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 6
ER -