Junin virus activity in rodents from endemic and nonendemic loci in central Argentina

J. N. Mills, B. A. Ellis, K. T. McKee, Thomas Ksiazek, J. G B Oro, J. I. Maiztegui, G. E. Calderon, C. J. Peters, J. E. Childs

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species. Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodonazarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward.

Original languageEnglish (US)
Pages (from-to)589-597
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume44
Issue number6
StatePublished - 1991
Externally publishedYes

Fingerprint

Junin virus
Argentina
Rodentia
Fever
Enzyme-Linked Immunosorbent Assay
Hemorrhagic Fever with Renal Syndrome
Antigens
Body Fluids
Immunoenzyme Techniques
Mammals
Maintenance
Viruses
Incidence
Infection
Population

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Mills, J. N., Ellis, B. A., McKee, K. T., Ksiazek, T., Oro, J. G. B., Maiztegui, J. I., ... Childs, J. E. (1991). Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. American Journal of Tropical Medicine and Hygiene, 44(6), 589-597.

Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. / Mills, J. N.; Ellis, B. A.; McKee, K. T.; Ksiazek, Thomas; Oro, J. G B; Maiztegui, J. I.; Calderon, G. E.; Peters, C. J.; Childs, J. E.

In: American Journal of Tropical Medicine and Hygiene, Vol. 44, No. 6, 1991, p. 589-597.

Research output: Contribution to journalArticle

Mills, JN, Ellis, BA, McKee, KT, Ksiazek, T, Oro, JGB, Maiztegui, JI, Calderon, GE, Peters, CJ & Childs, JE 1991, 'Junin virus activity in rodents from endemic and nonendemic loci in central Argentina', American Journal of Tropical Medicine and Hygiene, vol. 44, no. 6, pp. 589-597.
Mills, J. N. ; Ellis, B. A. ; McKee, K. T. ; Ksiazek, Thomas ; Oro, J. G B ; Maiztegui, J. I. ; Calderon, G. E. ; Peters, C. J. ; Childs, J. E. / Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. In: American Journal of Tropical Medicine and Hygiene. 1991 ; Vol. 44, No. 6. pp. 589-597.
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