Juvenile Niemann-Pick Disease With Vertical Supranuclear Ophthalmoplegia: Two Case Reports and Review of the Literature

Lenore Breen, Harold H. Morris, Jack B. Alperin, Sydney S. Schochet

Research output: Contribution to journalArticle

27 Scopus citations


Examination of two siblings who had histories of progressive decline in speech, intelligence, and coordination disclosed vertical supranuclear ophthalmoplegia, hepatosplenomegaly, and signs of diffuse CNS dysfunction. Niemann-Pick “foam cells” were found in the bone marrow of both patients. The features of these cases correlate in appearance and clinical findings with those of 21 other previously reported cases, which are reviewed in this article. Knowledge of the clinical manifestations of this particular variety of Niemann-Pick disease should aid in its earlier diagnosis.

Original languageEnglish (US)
Pages (from-to)388-390
Number of pages3
JournalArchives of Neurology
Issue number6
StatePublished - Jun 1981


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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