@article{07c7842f0b2545db98dbab01c8603ef3,
title = "Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure",
abstract = "The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.",
author = "Stone, {Richard A.} and Tisher, {C. Craig} and Hawkins, {Hal K.} and Robinson, {Roscoe R.}",
note = "Funding Information: RICHARD A. STONE, M.D. C. CRAIG TISHER, M.D.* HAL K. HAWKINS, M.D., Ph.D. ROSCOE R. ROBINSON, M.D. Durham, North Carolina From the Division of Nephrology, Department of Mledicine and the Department of Pathology, Duke University Medical Center, Durham, North Carolina. This study was supported in part by U.S. Public Health Service Grants HL 11820 and AM 13845. Requests for reprints should be addressed to Dr. C. Craig Tisher, Box 3014, Duke University Medical Center, Durham, North Carolina 27710. Manuscript accepted September 5, 1973. * Recipient of Research Career Development Award HL 440074 from the U.S. Public Health Service.",
year = "1974",
month = jan,
doi = "10.1016/0002-9343(74)90757-8",
language = "English (US)",
volume = "56",
pages = "119--123",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "1",
}