Abstract
The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-123 |
| Number of pages | 5 |
| Journal | The American Journal of Medicine |
| Volume | 56 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure. / Stone, Richard A.; Tisher, C. Craig; Hawkins, Hal K.; Robinson, Roscoe R.
In: The American Journal of Medicine, Vol. 56, No. 1, 1974, p. 119-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure
AU - Stone, Richard A.
AU - Tisher, C. Craig
AU - Hawkins, Hal K.
AU - Robinson, Roscoe R.
PY - 1974
Y1 - 1974
N2 - The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.
AB - The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015971719&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(74)90757-8
DO - 10.1016/0002-9343(74)90757-8
M3 - Article
VL - 56
SP - 119
EP - 123
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 1
ER -