Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure

Richard A. Stone, C. Craig Tisher, Hal K. Hawkins, Roscoe R. Robinson

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalThe American Journal of Medicine
Volume56
Issue number1
DOIs
StatePublished - Jan 1974

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure'. Together they form a unique fingerprint.

  • Cite this