Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure

Richard A. Stone; C. Craig Tisher; Hal K. Hawkins; Roscoe R. Robinson

doi:10.1016/0002-9343(74)90757-8

Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure

Richard A. Stone, C. Craig Tisher, Hal K. Hawkins, Roscoe R. Robinson

Pathology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.

Original language	English (US)
Pages (from-to)	119-123
Number of pages	5
Journal	The American Journal of Medicine
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/0002-9343(74)90757-8
State	Published - Jan 1974

ASJC Scopus subject areas

Medicine(all)

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abstract = "The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.",

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