Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure

Richard A. Stone, C. Craig Tisher, Hal K. Hawkins, Roscoe R. Robinson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalThe American Journal of Medicine
Volume56
Issue number1
DOIs
StatePublished - 1974
Externally publishedYes

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Diffuse Scleroderma
Acute Kidney Injury
Hyperplasia
Kidney
Juxtaglomerular Apparatus
Azotemia
Renin-Angiotensin System
Renin
Biological Assay
Renal Insufficiency
Autopsy
Biopsy

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure. / Stone, Richard A.; Tisher, C. Craig; Hawkins, Hal K.; Robinson, Roscoe R.

In: The American Journal of Medicine, Vol. 56, No. 1, 1974, p. 119-123.

Research output: Contribution to journalArticle

Stone, Richard A. ; Tisher, C. Craig ; Hawkins, Hal K. ; Robinson, Roscoe R. / Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure. In: The American Journal of Medicine. 1974 ; Vol. 56, No. 1. pp. 119-123.
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