Kato-Katz and Lumbreras rapid sedimentation test to evaluate helminth prevalence in the setting of a school-based deworming program

Martha Lopez, Maria Luisa Morales, Monisha Konana, Paige Hoyer, Roberto Pineda-Reyes, A. Clinton White, Hector Hugo Garcia, Andres Guillermo Lescano, Eduardo Gotuzzo, Miguel Cabada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The sensitivity of the Kato-Katz test is suboptimal for the evaluation of intestinal helminth prevalence. Moreover, during mass deworming, as helminth egg burden decreases, the sensitivity is likely to decrease. The Lumbreras rapid sedimentation (Lumbreras) is a low-cost non-quantitative test, but may provide useful information in low burden areas. We compared the prevalence of intestinal helminth infections assessed by the Kato-Katz and the Lumbreras rapid sedimentation test on 3 stool specimens from each of 1083 children. The sensitivities were compared using the McNemar paired test. Using the combined outcome of the 3 different stool tests as the standard, Kato-Katz had lower sensitivity than Lumbreras rapid sedimentation tests for Ascaris lumbricoides (85.1% vs. 95.1%, p = 0.03), Hymenolepis nana (77.7% vs. 97.9%, p < 0.01), Trichuris trichura (41.7% vs. 100%, p = 0.01), hookworm (0% vs. 100%, p = 0.01), and Strongyloides stercoralis (0% vs. 88%, p < 0.01). Kato-Katz demonstrated significantly lower sensitivity, missing most T. trichiura, hookworm, and S. stercoralis infections. The combination of Kato-Katz and Lumbreras rapid sedimentation tests enables the detection of more intestinal helminths infections in post-deworming low prevalence areas.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalPathogens and Global Health
Volume110
Issue number3
DOIs
StatePublished - Apr 2 2016

Fingerprint

Helminths
Strongyloides stercoralis
Ancylostomatoidea
Infection
Hymenolepis nana
Ascaris lumbricoides
Trichuris
Ovum
Costs and Cost Analysis

Keywords

  • Kato-Katz
  • Lumbreras rapid sedimentation
  • Screening tests
  • Sensitivity
  • Soil-transmitted helminths

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Microbiology

Cite this

Kato-Katz and Lumbreras rapid sedimentation test to evaluate helminth prevalence in the setting of a school-based deworming program. / Lopez, Martha; Morales, Maria Luisa; Konana, Monisha; Hoyer, Paige; Pineda-Reyes, Roberto; White, A. Clinton; Garcia, Hector Hugo; Lescano, Andres Guillermo; Gotuzzo, Eduardo; Cabada, Miguel.

In: Pathogens and Global Health, Vol. 110, No. 3, 02.04.2016, p. 130-134.

Research output: Contribution to journalArticle

Lopez, Martha ; Morales, Maria Luisa ; Konana, Monisha ; Hoyer, Paige ; Pineda-Reyes, Roberto ; White, A. Clinton ; Garcia, Hector Hugo ; Lescano, Andres Guillermo ; Gotuzzo, Eduardo ; Cabada, Miguel. / Kato-Katz and Lumbreras rapid sedimentation test to evaluate helminth prevalence in the setting of a school-based deworming program. In: Pathogens and Global Health. 2016 ; Vol. 110, No. 3. pp. 130-134.
@article{86c7261f0fea403c925f309492548088,
title = "Kato-Katz and Lumbreras rapid sedimentation test to evaluate helminth prevalence in the setting of a school-based deworming program",
abstract = "The sensitivity of the Kato-Katz test is suboptimal for the evaluation of intestinal helminth prevalence. Moreover, during mass deworming, as helminth egg burden decreases, the sensitivity is likely to decrease. The Lumbreras rapid sedimentation (Lumbreras) is a low-cost non-quantitative test, but may provide useful information in low burden areas. We compared the prevalence of intestinal helminth infections assessed by the Kato-Katz and the Lumbreras rapid sedimentation test on 3 stool specimens from each of 1083 children. The sensitivities were compared using the McNemar paired test. Using the combined outcome of the 3 different stool tests as the standard, Kato-Katz had lower sensitivity than Lumbreras rapid sedimentation tests for Ascaris lumbricoides (85.1{\%} vs. 95.1{\%}, p = 0.03), Hymenolepis nana (77.7{\%} vs. 97.9{\%}, p < 0.01), Trichuris trichura (41.7{\%} vs. 100{\%}, p = 0.01), hookworm (0{\%} vs. 100{\%}, p = 0.01), and Strongyloides stercoralis (0{\%} vs. 88{\%}, p < 0.01). Kato-Katz demonstrated significantly lower sensitivity, missing most T. trichiura, hookworm, and S. stercoralis infections. The combination of Kato-Katz and Lumbreras rapid sedimentation tests enables the detection of more intestinal helminths infections in post-deworming low prevalence areas.",
keywords = "Kato-Katz, Lumbreras rapid sedimentation, Screening tests, Sensitivity, Soil-transmitted helminths",
author = "Martha Lopez and Morales, {Maria Luisa} and Monisha Konana and Paige Hoyer and Roberto Pineda-Reyes and White, {A. Clinton} and Garcia, {Hector Hugo} and Lescano, {Andres Guillermo} and Eduardo Gotuzzo and Miguel Cabada",
year = "2016",
month = "4",
day = "2",
doi = "10.1080/20477724.2016.1187361",
language = "English (US)",
volume = "110",
pages = "130--134",
journal = "Pathogens and Global Health",
issn = "2047-7724",
publisher = "Maney Publishing",
number = "3",

}

TY - JOUR

T1 - Kato-Katz and Lumbreras rapid sedimentation test to evaluate helminth prevalence in the setting of a school-based deworming program

AU - Lopez, Martha

AU - Morales, Maria Luisa

AU - Konana, Monisha

AU - Hoyer, Paige

AU - Pineda-Reyes, Roberto

AU - White, A. Clinton

AU - Garcia, Hector Hugo

AU - Lescano, Andres Guillermo

AU - Gotuzzo, Eduardo

AU - Cabada, Miguel

PY - 2016/4/2

Y1 - 2016/4/2

N2 - The sensitivity of the Kato-Katz test is suboptimal for the evaluation of intestinal helminth prevalence. Moreover, during mass deworming, as helminth egg burden decreases, the sensitivity is likely to decrease. The Lumbreras rapid sedimentation (Lumbreras) is a low-cost non-quantitative test, but may provide useful information in low burden areas. We compared the prevalence of intestinal helminth infections assessed by the Kato-Katz and the Lumbreras rapid sedimentation test on 3 stool specimens from each of 1083 children. The sensitivities were compared using the McNemar paired test. Using the combined outcome of the 3 different stool tests as the standard, Kato-Katz had lower sensitivity than Lumbreras rapid sedimentation tests for Ascaris lumbricoides (85.1% vs. 95.1%, p = 0.03), Hymenolepis nana (77.7% vs. 97.9%, p < 0.01), Trichuris trichura (41.7% vs. 100%, p = 0.01), hookworm (0% vs. 100%, p = 0.01), and Strongyloides stercoralis (0% vs. 88%, p < 0.01). Kato-Katz demonstrated significantly lower sensitivity, missing most T. trichiura, hookworm, and S. stercoralis infections. The combination of Kato-Katz and Lumbreras rapid sedimentation tests enables the detection of more intestinal helminths infections in post-deworming low prevalence areas.

AB - The sensitivity of the Kato-Katz test is suboptimal for the evaluation of intestinal helminth prevalence. Moreover, during mass deworming, as helminth egg burden decreases, the sensitivity is likely to decrease. The Lumbreras rapid sedimentation (Lumbreras) is a low-cost non-quantitative test, but may provide useful information in low burden areas. We compared the prevalence of intestinal helminth infections assessed by the Kato-Katz and the Lumbreras rapid sedimentation test on 3 stool specimens from each of 1083 children. The sensitivities were compared using the McNemar paired test. Using the combined outcome of the 3 different stool tests as the standard, Kato-Katz had lower sensitivity than Lumbreras rapid sedimentation tests for Ascaris lumbricoides (85.1% vs. 95.1%, p = 0.03), Hymenolepis nana (77.7% vs. 97.9%, p < 0.01), Trichuris trichura (41.7% vs. 100%, p = 0.01), hookworm (0% vs. 100%, p = 0.01), and Strongyloides stercoralis (0% vs. 88%, p < 0.01). Kato-Katz demonstrated significantly lower sensitivity, missing most T. trichiura, hookworm, and S. stercoralis infections. The combination of Kato-Katz and Lumbreras rapid sedimentation tests enables the detection of more intestinal helminths infections in post-deworming low prevalence areas.

KW - Kato-Katz

KW - Lumbreras rapid sedimentation

KW - Screening tests

KW - Sensitivity

KW - Soil-transmitted helminths

UR - http://www.scopus.com/inward/record.url?scp=84982262323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982262323&partnerID=8YFLogxK

U2 - 10.1080/20477724.2016.1187361

DO - 10.1080/20477724.2016.1187361

M3 - Article

C2 - 27376503

AN - SCOPUS:84982262323

VL - 110

SP - 130

EP - 134

JO - Pathogens and Global Health

JF - Pathogens and Global Health

SN - 2047-7724

IS - 3

ER -