KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Neuropathic pain that can be produced by a lesion or disease of somatosensory system is one of the major causes of disability in our society. However, current first-line treatments produce only partial pain relief in the majority of patients. Recent studies suggest that injury-induced hyperexcitability of primary sensory neuron is critical for the development and maintenance of neuropathic pain. KCNQ channels are widely expressed in primary sensory neurons and effectively modulate neuronal excitability. Thus, targeting KCNQ channels to treat neuropathic pain has been extensively investigated.

Original languageEnglish (US)
Title of host publicationThe Neurobiology, Physiology, and Psychology of Pain
PublisherElsevier
Pages3-12
Number of pages10
ISBN (Electronic)9780128210666
ISBN (Print)9780128206089
DOIs
StatePublished - Jan 1 2021

Keywords

  • KCNQ channels
  • Kv7 channels
  • Neuropathic pain
  • Nociceptors
  • Primary sensory neurons

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience

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