Abstract
Though HIV-1 is a sexually transmitted infection, the gut associated lymphoid tissue (GALT) that houses about 60% of the body's total immune cells is unequivocally the earliest and most important target of HIV-1. In this review we summarize recent data regarding the early events in HIV-1 pathogenesis, with special emphasis on pathogenic effects on the GALT.
Original language | English (US) |
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Pages (from-to) | 102-109 |
Number of pages | 8 |
Journal | Current Infectious Disease Reports |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2012 |
Externally published | Yes |
Keywords
- Adaptive immune system
- African green monkeys
- AIDS
- Antibodies
- B cells
- Chronic infection
- Dendritic cells
- Early/acute infection
- GALT
- HIV-1
- Immune activation
- Innate immune system
- Microbial translocation
- Natural killer cells
- Peak viremia
- Rhesus macaques
- SIV
- T cells
- Viral set-point
ASJC Scopus subject areas
- Infectious Diseases