Killing of cryptosporidium sporozoites by lactoferrin

Jose Luis Paredes, Hayley Sparks, A. Clinton White, Griselle Martinez-Traverso, Theresa Ochoa, Alejandro Castellanos

Research output: Contribution to journalArticle

Abstract

Intestinal infection caused by Cryptosporidium is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk. It has showed bacteriostatic and antimicrobial activity in the intestine. However, the effects of lactoferrin on the intestinal parasite Cryptosporidium have not been reported. In this study, we investigated the anticryptosporidial activity of human lactoferrin on different stages of Cryptosporidium. Physiologic concentrations of lactoferrin killed Cryptosporidium parvum sporozoites, but had no significant effect on oocysts viability or parasite intracellular development. Since sporozoites are essential for the infection process, our data reinforce the importance of breastfeeding and point to the potential of lactoferrin as a novel therapeutic agent for cryptosporidiosis.

Original languageEnglish (US)
Pages (from-to)774-776
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume97
Issue number3
DOIs
StatePublished - 2017

Fingerprint

Sporozoites
Cryptosporidium
Lactoferrin
Cryptosporidiosis
Parasites
Cryptosporidium parvum
Oocysts
Human Milk
Infection
Breast Feeding
Human Activities
Intestines
Diarrhea
Glycoproteins
Morbidity
Mortality
Therapeutics

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Killing of cryptosporidium sporozoites by lactoferrin. / Paredes, Jose Luis; Sparks, Hayley; White, A. Clinton; Martinez-Traverso, Griselle; Ochoa, Theresa; Castellanos, Alejandro.

In: American Journal of Tropical Medicine and Hygiene, Vol. 97, No. 3, 2017, p. 774-776.

Research output: Contribution to journalArticle

Paredes, Jose Luis ; Sparks, Hayley ; White, A. Clinton ; Martinez-Traverso, Griselle ; Ochoa, Theresa ; Castellanos, Alejandro. / Killing of cryptosporidium sporozoites by lactoferrin. In: American Journal of Tropical Medicine and Hygiene. 2017 ; Vol. 97, No. 3. pp. 774-776.
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