Kinesin: possible biological roles for a new microtubule motor

Ronald D. Vale, Jonathan M. Scholey, Michael Sheetz

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.

Original languageEnglish (US)
Pages (from-to)464-468
Number of pages5
JournalTrends in biochemical sciences
Volume11
Issue number11
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Kinesin
Microtubules
Organelles
Purification
Mitosis
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

Kinesin : possible biological roles for a new microtubule motor. / Vale, Ronald D.; Scholey, Jonathan M.; Sheetz, Michael.

In: Trends in biochemical sciences, Vol. 11, No. 11, 01.01.1986, p. 464-468.

Research output: Contribution to journalArticle

Vale, Ronald D. ; Scholey, Jonathan M. ; Sheetz, Michael. / Kinesin : possible biological roles for a new microtubule motor. In: Trends in biochemical sciences. 1986 ; Vol. 11, No. 11. pp. 464-468.
@article{519850043ab34a269f2b548cabba3b17,
title = "Kinesin: possible biological roles for a new microtubule motor",
abstract = "Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.",
author = "Vale, {Ronald D.} and Scholey, {Jonathan M.} and Michael Sheetz",
year = "1986",
month = "1",
day = "1",
doi = "10.1016/0968-0004(86)90248-3",
language = "English (US)",
volume = "11",
pages = "464--468",
journal = "Trends in Biochemical Sciences",
issn = "0376-5067",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Kinesin

T2 - possible biological roles for a new microtubule motor

AU - Vale, Ronald D.

AU - Scholey, Jonathan M.

AU - Sheetz, Michael

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.

AB - Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.

UR - http://www.scopus.com/inward/record.url?scp=0008801119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0008801119&partnerID=8YFLogxK

U2 - 10.1016/0968-0004(86)90248-3

DO - 10.1016/0968-0004(86)90248-3

M3 - Article

AN - SCOPUS:0008801119

VL - 11

SP - 464

EP - 468

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0376-5067

IS - 11

ER -