Kinetics of Circulating Adhesion Molecules and Chemokines after Mechanical Trauma and Burns

Christian Schinkel, Eugen Faist, Svenja Zimmer, Stefan Piltz, Alfred Walz, Richard Rose, Eduard Höcherl, David Herndon, Friedrich Wilhelm Schildberg

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: To assess the role of circulating adhesion molecules and chemotactic cytokines within different settings of major trauma. Design: Retrospective study. Setting: Teaching hospitals, USA and Germany. Subjects: Two groups of patients with multiple injuries (group I n = 155 and group II n = 12) with mean (SEM) injury severity scores (ISS) of 35 (4) and 32 (4) points, respectively, and 18 burned patients with a mean of ISS 38 (9) points. Interventions: Serum samples were collected at the site of the accident and on admission to the (Group I) as well as during the post-trauma course in the hospital (Group II: days 1, 3, 5, 7, 10; Group III: weekly, up to week 10). Main outcome measures: Measurement of concentrations of soluble (s) adhesion molecules (sE-selectin, sP-selectin), and chemotactic cytokines (interleukin-8 [IL-8], epithelial cell derived neutrophil activating peptide 78 [ENA-78]) in serum after major mechanical trauma and burns. Results: High concentrations of ENA-78 and sP-selectin were already present at the site of accident as well as one hour after injury. During recovery from the injuries, persistently high concentrations of IL-8, ENA-78, and sP-selectin were found, but sE-selectin was increased only during the first week after major trauma. Conclusion: Massive tissue trauma causes immediate activation of selected chemokines and adhesion molecules within minutes of the injury which will then persist depending on the type and severity of the injury for a substantial length of time. There was, however, no correlation between serum concentrations of the mediators investigated and susceptibility to complications or outcome.

Original languageEnglish
Pages (from-to)763-768
Number of pages6
JournalEuropean Journal of Surgery
Volume162
Issue number10
StatePublished - 1996
Externally publishedYes

Fingerprint

Burns
Chemokines
Selectins
Wounds and Injuries
Injury Severity Score
Interleukin-8
Accidents
Serum
Multiple Trauma
Teaching Hospitals
Germany
Neutrophils
Retrospective Studies
Epithelial Cells
Outcome Assessment (Health Care)

Keywords

  • Burn trauma
  • ENA-78
  • Interleukin-8
  • Predictive roles
  • Serum amyloid A (SAA)
  • Soluble E-selectin
  • Soluble P-selectin
  • Trauma

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Schinkel, C., Faist, E., Zimmer, S., Piltz, S., Walz, A., Rose, R., ... Schildberg, F. W. (1996). Kinetics of Circulating Adhesion Molecules and Chemokines after Mechanical Trauma and Burns. European Journal of Surgery, 162(10), 763-768.

Kinetics of Circulating Adhesion Molecules and Chemokines after Mechanical Trauma and Burns. / Schinkel, Christian; Faist, Eugen; Zimmer, Svenja; Piltz, Stefan; Walz, Alfred; Rose, Richard; Höcherl, Eduard; Herndon, David; Schildberg, Friedrich Wilhelm.

In: European Journal of Surgery, Vol. 162, No. 10, 1996, p. 763-768.

Research output: Contribution to journalArticle

Schinkel, C, Faist, E, Zimmer, S, Piltz, S, Walz, A, Rose, R, Höcherl, E, Herndon, D & Schildberg, FW 1996, 'Kinetics of Circulating Adhesion Molecules and Chemokines after Mechanical Trauma and Burns', European Journal of Surgery, vol. 162, no. 10, pp. 763-768.
Schinkel C, Faist E, Zimmer S, Piltz S, Walz A, Rose R et al. Kinetics of Circulating Adhesion Molecules and Chemokines after Mechanical Trauma and Burns. European Journal of Surgery. 1996;162(10):763-768.
Schinkel, Christian ; Faist, Eugen ; Zimmer, Svenja ; Piltz, Stefan ; Walz, Alfred ; Rose, Richard ; Höcherl, Eduard ; Herndon, David ; Schildberg, Friedrich Wilhelm. / Kinetics of Circulating Adhesion Molecules and Chemokines after Mechanical Trauma and Burns. In: European Journal of Surgery. 1996 ; Vol. 162, No. 10. pp. 763-768.
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AU - Walz, Alfred

AU - Rose, Richard

AU - Höcherl, Eduard

AU - Herndon, David

AU - Schildberg, Friedrich Wilhelm

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N2 - Objective: To assess the role of circulating adhesion molecules and chemotactic cytokines within different settings of major trauma. Design: Retrospective study. Setting: Teaching hospitals, USA and Germany. Subjects: Two groups of patients with multiple injuries (group I n = 155 and group II n = 12) with mean (SEM) injury severity scores (ISS) of 35 (4) and 32 (4) points, respectively, and 18 burned patients with a mean of ISS 38 (9) points. Interventions: Serum samples were collected at the site of the accident and on admission to the (Group I) as well as during the post-trauma course in the hospital (Group II: days 1, 3, 5, 7, 10; Group III: weekly, up to week 10). Main outcome measures: Measurement of concentrations of soluble (s) adhesion molecules (sE-selectin, sP-selectin), and chemotactic cytokines (interleukin-8 [IL-8], epithelial cell derived neutrophil activating peptide 78 [ENA-78]) in serum after major mechanical trauma and burns. Results: High concentrations of ENA-78 and sP-selectin were already present at the site of accident as well as one hour after injury. During recovery from the injuries, persistently high concentrations of IL-8, ENA-78, and sP-selectin were found, but sE-selectin was increased only during the first week after major trauma. Conclusion: Massive tissue trauma causes immediate activation of selected chemokines and adhesion molecules within minutes of the injury which will then persist depending on the type and severity of the injury for a substantial length of time. There was, however, no correlation between serum concentrations of the mediators investigated and susceptibility to complications or outcome.

AB - Objective: To assess the role of circulating adhesion molecules and chemotactic cytokines within different settings of major trauma. Design: Retrospective study. Setting: Teaching hospitals, USA and Germany. Subjects: Two groups of patients with multiple injuries (group I n = 155 and group II n = 12) with mean (SEM) injury severity scores (ISS) of 35 (4) and 32 (4) points, respectively, and 18 burned patients with a mean of ISS 38 (9) points. Interventions: Serum samples were collected at the site of the accident and on admission to the (Group I) as well as during the post-trauma course in the hospital (Group II: days 1, 3, 5, 7, 10; Group III: weekly, up to week 10). Main outcome measures: Measurement of concentrations of soluble (s) adhesion molecules (sE-selectin, sP-selectin), and chemotactic cytokines (interleukin-8 [IL-8], epithelial cell derived neutrophil activating peptide 78 [ENA-78]) in serum after major mechanical trauma and burns. Results: High concentrations of ENA-78 and sP-selectin were already present at the site of accident as well as one hour after injury. During recovery from the injuries, persistently high concentrations of IL-8, ENA-78, and sP-selectin were found, but sE-selectin was increased only during the first week after major trauma. Conclusion: Massive tissue trauma causes immediate activation of selected chemokines and adhesion molecules within minutes of the injury which will then persist depending on the type and severity of the injury for a substantial length of time. There was, however, no correlation between serum concentrations of the mediators investigated and susceptibility to complications or outcome.

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