Kinetics of soluble interleukin-2 receptor after mechanical and burn trauma

Christian Schinkel, Svenja Zimmer, Paul J. Durda, E. Höcherl, David Herndon, Eugen Faist

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Extended trauma causes a failure of T-lymphocyte function due to suppressed interleukin-2 synthesis; however, the role of IL-2 receptor, especially its soluble form (sIL-2R), needs to be further evaluated. It was the objective of the study to assess the kinetics of sIL-2R within different settings of trauma and to define its clinical value and possible predictive role. Three groups of patients with trauma were included in the study. Groups 1 and 2 consisted of multiply injured patients (injury severity score 35 ± 4 and 32 ± 4, respectively); burned patients formed group 3 (injury severity score 38 ± 9). Serum samples were collected at the site of the accident (group 1) and during the posttrauma course in the hospital (group 2, daily; group 3, weekly) and sIL-2R was measured in these samples. sIL-2R was within the normal range in groups 1 and 2, but was significantly increased in group 3. There was no correlation between serum concentrations of this mediator and susceptibility to infectious complications or outcome.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume18
Issue number3
DOIs
StatePublished - May 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

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