TY - JOUR
T1 - Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease
T2 - A Review
AU - Fung, Tsz Yan
AU - Iyaswamy, Ashok
AU - Sreenivasmurthy, Sravan G.
AU - Krishnamoorthi, Senthilkumar
AU - Guan, Xin Jie
AU - Zhu, Zhou
AU - Su, Cheng Fu
AU - Liu, Jia
AU - Kan, Yuxuan
AU - Zhang, Yuan
AU - Wong, Hoi Leong Xavier
AU - Li, Min
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3
Y1 - 2022/3
N2 - Alzheimer’s disease (AD) is an age-associated neurodegenerative disease; it is the most common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily generated in the brain and kidney, is active in a variety of metabolic pathways involved in controlling neurodegeneration and ageing. Recently, many studies have found that the upregulation of Klotho can improve pathological cognitive deficits in an AD mice model and have demonstrated that Klotho plays a role in the induction of autophagy, a major contributing factor for AD. Despite the close association between Klotho and neurodegenerative diseases, such as AD, the underlying mechanism by which Klotho contributes to AD remains poorly understood. In this paper, we will introduce the expression, location and structure of Klotho and its biological functions. Specifically, this review is devoted to the correlation of Klotho protein and the AD phenotype, such as the effect of Klotho in upregulating the amyloid-beta clearance and in inducing autophagy for the clearance of toxic proteins, by regulating the autophagy lysosomal pathway (ALP). In summary, the results of multiple studies point out that targeting Klotho would be a potential therapeutic strategy in AD treatment.
AB - Alzheimer’s disease (AD) is an age-associated neurodegenerative disease; it is the most common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily generated in the brain and kidney, is active in a variety of metabolic pathways involved in controlling neurodegeneration and ageing. Recently, many studies have found that the upregulation of Klotho can improve pathological cognitive deficits in an AD mice model and have demonstrated that Klotho plays a role in the induction of autophagy, a major contributing factor for AD. Despite the close association between Klotho and neurodegenerative diseases, such as AD, the underlying mechanism by which Klotho contributes to AD remains poorly understood. In this paper, we will introduce the expression, location and structure of Klotho and its biological functions. Specifically, this review is devoted to the correlation of Klotho protein and the AD phenotype, such as the effect of Klotho in upregulating the amyloid-beta clearance and in inducing autophagy for the clearance of toxic proteins, by regulating the autophagy lysosomal pathway (ALP). In summary, the results of multiple studies point out that targeting Klotho would be a potential therapeutic strategy in AD treatment.
KW - Alzheimer’s disease
KW - Klotho
KW - autophagy
KW - autophagy lysosomal pathway (ALP)
KW - neurodegenerative disease
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U2 - 10.3390/biomedicines10030705
DO - 10.3390/biomedicines10030705
M3 - Review article
C2 - 35327507
AN - SCOPUS:85127433248
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 3
M1 - 705
ER -