l-Arginine prevents metabolic effects of high glucose in diabetic mice

Matthew B. West, Kota Ramana, Karin Kaiserova, Satish Srivastava, Aruni Bhatnagar

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We tested the hypothesis that activation of the polyol pathway and protein kinase C (PKC) during diabetes is due to loss of NO. Our results show that after 4 weeks of streptozotocin-induced diabetes, treatment with l-arginine restored NO levels and prevented tissue accumulation of sorbitol in mice, which was accompanied by an increase in glutathiolation of aldose reductase. l-Arginine treatment decreased superoxide generation in the aorta, total PKC activity and PKC-βII phosphorylation in the heart, and the plasma levels of triglycerides and soluble ICAM. These data suggest that increasing NO bioavailability by l-arginine corrects the major biochemical abnormalities of diabetes.

Original languageEnglish (US)
Pages (from-to)2609-2614
Number of pages6
JournalFEBS Letters
Volume582
Issue number17
DOIs
StatePublished - Jul 23 2008

Fingerprint

Medical problems
Protein Kinase C
Arginine
Glucose
Aldehyde Reductase
Phosphorylation
Experimental Diabetes Mellitus
Sorbitol
Streptozocin
Superoxides
Biological Availability
Aorta
Triglycerides
Chemical activation
Tissue
Plasmas

Keywords

  • Cell adhesion molecule
  • Diabetes mellitus
  • Inflammation
  • Nitric oxide
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

l-Arginine prevents metabolic effects of high glucose in diabetic mice. / West, Matthew B.; Ramana, Kota; Kaiserova, Karin; Srivastava, Satish; Bhatnagar, Aruni.

In: FEBS Letters, Vol. 582, No. 17, 23.07.2008, p. 2609-2614.

Research output: Contribution to journalArticle

West, MB, Ramana, K, Kaiserova, K, Srivastava, S & Bhatnagar, A 2008, 'l-Arginine prevents metabolic effects of high glucose in diabetic mice', FEBS Letters, vol. 582, no. 17, pp. 2609-2614. https://doi.org/10.1016/j.febslet.2008.06.039
West, Matthew B. ; Ramana, Kota ; Kaiserova, Karin ; Srivastava, Satish ; Bhatnagar, Aruni. / l-Arginine prevents metabolic effects of high glucose in diabetic mice. In: FEBS Letters. 2008 ; Vol. 582, No. 17. pp. 2609-2614.
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