L-iduronidase in cultured human fibroblasts and liver

Reuben Matalon, J. A. Cifonelli, Albert Dorfman

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Extracts of normal human livers and skin fibroblasts cultured from normal individuals and patients with the Hurler syndrome released L-iduronic acid when incubated with desulfated dermatan sulfate. Enzyme extracts of normal fibroblasts liberated larger amounts of L-induronic acid, as judged by paper chromatography, than did homogenates from Hurler fibroblasts. Preliminary studies with desulfated heparan sulfate using the same enzyme systems have also shown material with the Rf of iduronolactone on paper chromatography.

Original languageEnglish (US)
Pages (from-to)340-345
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume42
Issue number2
DOIs
StatePublished - Jan 22 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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