L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Timothy Brannan; Anish Bhardwaj; Melvin D. Yahr

doi:10.1212/wnl.40.7.1134

L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Timothy Brannan
, Anish Bhardwaj
, Melvin D. Yahr

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.

Original language	English (US)
Pages (from-to)	1134-1135
Number of pages	2
Journal	Neurology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1212/wnl.40.7.1134
State	Published - Jul 1990
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.40.7.1134

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@article{1b9a98a9e6dd46509e5575abc0817aeb,

title = "L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study",

abstract = "Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.",

author = "Timothy Brannan and Anish Bhardwaj and Yahr, \{Melvin D.\}",

year = "1990",

month = jul,

doi = "10.1212/wnl.40.7.1134",

language = "English (US)",

volume = "40",

pages = "1134--1135",

journal = "Neurology",

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publisher = "Lippincott Williams and Wilkins",

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T1 - L-threodops increases extracellular norepinephrine levels in the brain

T2 - An in vivo study

AU - Brannan, Timothy

AU - Bhardwaj, Anish

AU - Yahr, Melvin D.

PY - 1990/7

Y1 - 1990/7

N2 - Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.

AB - Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.

UR - https://www.scopus.com/pages/publications/0025295867

UR - https://www.scopus.com/pages/publications/0025295867#tab=citedBy

U2 - 10.1212/wnl.40.7.1134

DO - 10.1212/wnl.40.7.1134

M3 - Article

C2 - 2113206

AN - SCOPUS:0025295867

SN - 0028-3878

VL - 40

SP - 1134

EP - 1135

JO - Neurology

JF - Neurology

IS - 7

ER -

L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Abstract

ASJC Scopus subject areas

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