Abstract
We studied 230 independently living healthy elderly men and women to examine the hypothesis that subclinical nutritional deficiencies contributed to depressed immune function seen in the elderly. Immunologic function was assessed with delayed type hypersensitivity skin testing to four antigens, in vitro lymphocyte culture with phytohemagglutinin, lymphocyte count, and presence of serum autoantibodies and circulating immune complexes. Nutritional status was assessed by 3-day diet records and also biochemical analyses of blood for vitamins A, B12, C, D, E, riboflavin, folic acid, and the minerals iron, copper, and zinc. Using a variety of analyses we found no association between malnutrition and depressed immunologic function in this population. We conclude that subtle nutritional deficiency is not a noticeable contributor to the immunodeficiency of aging, and that previously reported beneficial effects of "megadose" nutritional supplements on the immune response of elderly individuals probably represent a pharmacologic effect rather than the correction of nutritional deficiencies.
| Original language | English (US) |
|---|---|
| Journal | Journals of Gerontology |
| Volume | 43 |
| Issue number | 2 |
| State | Published - Mar 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Aging
Cite this
Lack of correlation between indices of nutritional status and immunologic function in elderly humans. / Goodwin, James; Garry, P. J.
In: Journals of Gerontology, Vol. 43, No. 2, 03.1988.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of correlation between indices of nutritional status and immunologic function in elderly humans.
AU - Goodwin, James
AU - Garry, P. J.
PY - 1988/3
Y1 - 1988/3
N2 - We studied 230 independently living healthy elderly men and women to examine the hypothesis that subclinical nutritional deficiencies contributed to depressed immune function seen in the elderly. Immunologic function was assessed with delayed type hypersensitivity skin testing to four antigens, in vitro lymphocyte culture with phytohemagglutinin, lymphocyte count, and presence of serum autoantibodies and circulating immune complexes. Nutritional status was assessed by 3-day diet records and also biochemical analyses of blood for vitamins A, B12, C, D, E, riboflavin, folic acid, and the minerals iron, copper, and zinc. Using a variety of analyses we found no association between malnutrition and depressed immunologic function in this population. We conclude that subtle nutritional deficiency is not a noticeable contributor to the immunodeficiency of aging, and that previously reported beneficial effects of "megadose" nutritional supplements on the immune response of elderly individuals probably represent a pharmacologic effect rather than the correction of nutritional deficiencies.
AB - We studied 230 independently living healthy elderly men and women to examine the hypothesis that subclinical nutritional deficiencies contributed to depressed immune function seen in the elderly. Immunologic function was assessed with delayed type hypersensitivity skin testing to four antigens, in vitro lymphocyte culture with phytohemagglutinin, lymphocyte count, and presence of serum autoantibodies and circulating immune complexes. Nutritional status was assessed by 3-day diet records and also biochemical analyses of blood for vitamins A, B12, C, D, E, riboflavin, folic acid, and the minerals iron, copper, and zinc. Using a variety of analyses we found no association between malnutrition and depressed immunologic function in this population. We conclude that subtle nutritional deficiency is not a noticeable contributor to the immunodeficiency of aging, and that previously reported beneficial effects of "megadose" nutritional supplements on the immune response of elderly individuals probably represent a pharmacologic effect rather than the correction of nutritional deficiencies.
UR - http://www.scopus.com/inward/record.url?scp=0023970754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023970754&partnerID=8YFLogxK
M3 - Article
C2 - 3346522
AN - SCOPUS:0023970754
VL - 43
JO - Journal of Gerontology: Social Sciences
JF - Journal of Gerontology: Social Sciences
SN - 0022-1422
IS - 2
ER -