Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain

S. Abdi, D. H. Lee, S. K. Park, J. M. Chung

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We investigated the significance of pre-emptive analgesia using a well-known model of neuropathic pain in rats. Lignocaine, bupivacaine or saline was applied locally to the left L5-L6 spinal nerve before or 4 days after nerve injury. Mechanical allodynia was then evaluated before and after injury. Pre- and post-injury treatment with local anaesthetics both resulted in a two- to threefold increase in the pain threshold, as manifested by a significant increase in von Frey measurements. However, this effect lasted only 24 h. Our study in rats questions the beneficial effect of a single dose of local anaesthetic as pre-emptive analgesia.

Original languageEnglish (US)
Pages (from-to)620-623
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number4
StatePublished - 2000
Externally publishedYes


  • Anaesthetics local
  • Bupivacaine
  • Lignocaine
  • Neuropathic
  • Pain
  • Rats

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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