Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain

S. Abdi, D. H. Lee, S. K. Park, Jin Chung

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We investigated the significance of pre-emptive analgesia using a well-known model of neuropathic pain in rats. Lignocaine, bupivacaine or saline was applied locally to the left L5-L6 spinal nerve before or 4 days after nerve injury. Mechanical allodynia was then evaluated before and after injury. Pre- and post-injury treatment with local anaesthetics both resulted in a two- to threefold increase in the pain threshold, as manifested by a significant increase in von Frey measurements. However, this effect lasted only 24 h. Our study in rats questions the beneficial effect of a single dose of local anaesthetic as pre-emptive analgesia.

Original languageEnglish (US)
Pages (from-to)620-623
Number of pages4
JournalBritish Journal of Anaesthesia
Volume85
Issue number4
StatePublished - 2000

Fingerprint

Neuralgia
Local Anesthetics
Analgesics
Wounds and Injuries
Analgesia
Spinal Nerves
Pain Threshold
Bupivacaine
Hyperalgesia
Lidocaine
Therapeutics

Keywords

  • Anaesthetics local
  • Bupivacaine
  • Lignocaine
  • Neuropathic
  • Pain
  • Rats

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain. / Abdi, S.; Lee, D. H.; Park, S. K.; Chung, Jin.

In: British Journal of Anaesthesia, Vol. 85, No. 4, 2000, p. 620-623.

Research output: Contribution to journalArticle

Abdi, S. ; Lee, D. H. ; Park, S. K. ; Chung, Jin. / Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain. In: British Journal of Anaesthesia. 2000 ; Vol. 85, No. 4. pp. 620-623.
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