Abstract
Langat (LGT) virus M protein has been generated in a recombinant system. Antiserum raised against the LGT virus M protein neutralizes tick-borne encephalitis serocomplex flaviviruses but not mosquito-borne flaviviruses, indicating that the M protein is exposed on the surface of virions. The antiserum recognizes intracellular LGT virus prM/M and binds to prM and M in Western blots of whole-cell lysates and purified virus, respectively. These data suggest that the prM and M proteins are structurally similar under native conditions and support the hypothesis that the "pr" portion of prM facilitates proper folding of the M protein for expression on the virion surface.
Original language | English (US) |
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Pages (from-to) | 3999-4001 |
Number of pages | 3 |
Journal | Journal of virology |
Volume | 75 |
Issue number | 8 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology