Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Xiaotian Zhang; Mira Jeong; Xingfan Huang; Xue Qing Wang; Xinyu Wang; Wanding Zhou; Muhammad S. Shamim; Haley Gore; Pamela Himadewi; Yushuai Liu; Ivan D. Bochkov; Jaime Reyes; Madison Doty; Yung Hsin Huang; Haiyoung Jung; Emily Heikamp; Aviva Presser Aiden; Wei Li; Jianzhong Su; Erez Lieberman Aiden; Margaret A. Goodell

doi:10.1016/j.molcel.2020.04.018

Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Xiaotian Zhang
, Mira Jeong
, Xingfan Huang
, Xue Qing Wang
, Xinyu Wang
, Wanding Zhou
, Muhammad S. Shamim
, Haley Gore
, Pamela Himadewi
, Yushuai Liu
, Ivan D. Bochkov
, Jaime Reyes
, Madison Doty
, Yung Hsin Huang
, Haiyoung Jung
, Emily Heikamp
, Aviva Presser Aiden
, Wei Li
, Jianzhong Su
, Erez Lieberman Aiden

Margaret A. Goodell

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Zhang et al. discovered that very large DNA methylation nadirs (grand canyons) form megabase-scale and inter-chromosomal 3D genomic interactions in primary stem and progenitor cells. H3K27me3 is strongly enriched in grand canyons and is important for organizing the grand canyon interactions associated with their stem cell state.

Original language	English (US)
Pages (from-to)	506-521.e6
Journal	Molecular cell
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.04.018
State	Published - May 7 2020
Externally published	Yes

Keywords

3D genomics
CpG
DNA methylation
DNA methylation canyon
Polycomb
chromosomal looping
hematopoietic
self-renewal
stem cells

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.04.018

Cite this

Zhang, X., Jeong, M., Huang, X., Wang, X. Q., Wang, X., Zhou, W., Shamim, M. S., Gore, H., Himadewi, P., Liu, Y., Bochkov, I. D., Reyes, J., Doty, M., Huang, Y. H., Jung, H., Heikamp, E., Aiden, A. P., Li, W., Su, J., ... Goodell, M. A. (2020). Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity. Molecular cell, 78(3), 506-521.e6. https://doi.org/10.1016/j.molcel.2020.04.018

Zhang, X, Jeong, M, Huang, X, Wang, XQ, Wang, X, Zhou, W, Shamim, MS, Gore, H, Himadewi, P, Liu, Y, Bochkov, ID, Reyes, J, Doty, M, Huang, YH, Jung, H, Heikamp, E, Aiden, AP, Li, W, Su, J, Aiden, EL & Goodell, MA 2020, 'Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity', Molecular cell, vol. 78, no. 3, pp. 506-521.e6. https://doi.org/10.1016/j.molcel.2020.04.018

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title = "Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity",

abstract = "Zhang et al. discovered that very large DNA methylation nadirs (grand canyons) form megabase-scale and inter-chromosomal 3D genomic interactions in primary stem and progenitor cells. H3K27me3 is strongly enriched in grand canyons and is important for organizing the grand canyon interactions associated with their stem cell state.",

keywords = "3D genomics, CpG, DNA methylation, DNA methylation canyon, Polycomb, chromosomal looping, hematopoietic, self-renewal, stem cells",

author = "Xiaotian Zhang and Mira Jeong and Xingfan Huang and Wang, \{Xue Qing\} and Xinyu Wang and Wanding Zhou and Shamim, \{Muhammad S.\} and Haley Gore and Pamela Himadewi and Yushuai Liu and Bochkov, \{Ivan D.\} and Jaime Reyes and Madison Doty and Huang, \{Yung Hsin\} and Haiyoung Jung and Emily Heikamp and Aiden, \{Aviva Presser\} and Wei Li and Jianzhong Su and Aiden, \{Erez Lieberman\} and Goodell, \{Margaret A.\}",

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doi = "10.1016/j.molcel.2020.04.018",

language = "English (US)",

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AU - Zhang, Xiaotian

AU - Jeong, Mira

AU - Huang, Xingfan

AU - Wang, Xue Qing

AU - Wang, Xinyu

AU - Zhou, Wanding

AU - Shamim, Muhammad S.

AU - Gore, Haley

AU - Himadewi, Pamela

AU - Liu, Yushuai

AU - Bochkov, Ivan D.

AU - Reyes, Jaime

AU - Doty, Madison

AU - Huang, Yung Hsin

AU - Jung, Haiyoung

AU - Heikamp, Emily

AU - Aiden, Aviva Presser

AU - Li, Wei

AU - Su, Jianzhong

AU - Aiden, Erez Lieberman

AU - Goodell, Margaret A.

PY - 2020/5/7

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AB - Zhang et al. discovered that very large DNA methylation nadirs (grand canyons) form megabase-scale and inter-chromosomal 3D genomic interactions in primary stem and progenitor cells. H3K27me3 is strongly enriched in grand canyons and is important for organizing the grand canyon interactions associated with their stem cell state.

KW - 3D genomics

KW - CpG

KW - DNA methylation

KW - DNA methylation canyon

KW - Polycomb

KW - chromosomal looping

KW - hematopoietic

KW - self-renewal

KW - stem cells

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JO - Molecular cell

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ER -

Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Abstract

Keywords

ASJC Scopus subject areas

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