Laser fluence for permanent damage of cutaneous blood vessels

Jennifer Kehlet Barton, Gracie Vargas, T. Joshua Pfefer, Ashley J. Welch

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Treatment of vascular disorders may be improved by a more thorough understanding of laser-blood vessel interaction. In this study, the probability of permanent damage to a given type and size of blood vessel was determined as a function of fluence at the top (superficial edge) of the vessel lumen. A 532 nm wavelength, 10 ms pulse duration, 3 mm spot size laser was used to perform approximately 250 irradiations of subdermal blood vessels in the hamster dorsal skin flap preparation. The radiant exposure required for a 50% probability of permanent damage was calculated using a probit analysis of experimental results. Threshold radiant exposure increased with larger blood vessel diameters and was greater for arterioles than venules. Monte Carlo modeling of a typical blood vessel geometry revealed that fluence at the top of the blood vessel lumen was amplified by a factor of approximately 2.4 over tissue surface radiant exposure, due to light scattering in the tissue and internal reflection at the skin-air interfaces.

Original languageEnglish (US)
Pages (from-to)916-920
Number of pages5
JournalPhotochemistry and Photobiology
Volume70
Issue number6
DOIs
StatePublished - Dec 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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