Laser initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues

John M. Kokosa, Andrzej Przyjazny, Kenneth E. Bartels, Massoud Motamedi, Donald J. Hayes, David B. Wallace, Christopher J. Frederickson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Organic dyes have found increasing use a s sensitizers in laser surgical procedures, due to their high optical absorbances. Little is known, however, about the nature of the degradation products formed when these dyes are irradiated with a laser. Previous work in our laboratories has shown that irradiation of polymeric and biological tissues with CO 2 and Nd:YAG lasers produces a host of volatile and semivolatile by-products, some of which are known to be potential carcinogens. This work focuses on the identification of the chemical by-products formed by diode laser (805 nm) and Nd:YAG (1.06 μm) laser irradiation of indocyanine green (ICG) and carbon black based ink sensitized tissues, including bone, tendon and sheep's teeth. Samples were mounted in a 0.5-L Pyrex sample chamber equipped with quartz optical windows, charcoal filtered air inlet and an outlet attached to an appropriate sample trap and a constant flow pump. By-products were analyzed by GC/MS and HPLC. Volatiles identified included benzene and formaldehyde. Semi-volatiles included traces of polycyclic aromatics, arising from the biological matrix and inks, as well as fragments of ICG and the carbon ink components. The significance of these results will be discussed, including the necessity of using appropriate evacuation devices when utilizing lasers for surgical procedures.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages205-213
Number of pages9
Volume2974
DOIs
StatePublished - 1997
EventLaser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment - San Jose, CA, United States
Duration: Feb 10 1997Feb 10 1997

Other

OtherLaser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment
CountryUnited States
CitySan Jose, CA
Period2/10/972/10/97

Fingerprint

Soot
Indocyanine Green
Biological Tissue
Carbon black
Volatiles
Carbon
inks
Ink
Tissue
Laser
Decomposition
Byproducts
decomposition
Decompose
Lasers
carbon
products
Dyes
Irradiation
lasers

Keywords

  • Benzene
  • Carbon black
  • Chemical by-products
  • Dyes
  • Formaldehyde
  • Indocyanine green
  • Laser

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Kokosa, J. M., Przyjazny, A., Bartels, K. E., Motamedi, M., Hayes, D. J., Wallace, D. B., & Frederickson, C. J. (1997). Laser initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2974, pp. 205-213) https://doi.org/10.1117/12.275244

Laser initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues. / Kokosa, John M.; Przyjazny, Andrzej; Bartels, Kenneth E.; Motamedi, Massoud; Hayes, Donald J.; Wallace, David B.; Frederickson, Christopher J.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2974 1997. p. 205-213.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kokosa, JM, Przyjazny, A, Bartels, KE, Motamedi, M, Hayes, DJ, Wallace, DB & Frederickson, CJ 1997, Laser initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2974, pp. 205-213, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, San Jose, CA, United States, 2/10/97. https://doi.org/10.1117/12.275244
Kokosa JM, Przyjazny A, Bartels KE, Motamedi M, Hayes DJ, Wallace DB et al. Laser initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2974. 1997. p. 205-213 https://doi.org/10.1117/12.275244
Kokosa, John M. ; Przyjazny, Andrzej ; Bartels, Kenneth E. ; Motamedi, Massoud ; Hayes, Donald J. ; Wallace, David B. ; Frederickson, Christopher J. / Laser initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2974 1997. pp. 205-213
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