Laser opto-acoustic tomography for medical diagnostics

experiments with biological tissues

Rinat Esenaliev, Alexander A. Oraevsky, Steven L. Jacques, Frank K. Tittel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Citations (Scopus)

Abstract

Feasibility of laser optoacoustic tomography to detect turbid tissues with different optical properties was experimentally investigated using real biological tissues. The following abilities of this technique were quantitatively studied: maximal depth of optoacoustic signal detection, acoustic attenuation of laser-induced pressure waves, and limit of resolution. Two types of biological tissues were used for the experiments: chicken breast muscle as a tissue with low absorption coefficient and bovine liver as a tissue with higher absorption coefficient. Tissue samples were irradiated by Q-switched Nd:YAG-laser pulses to satisfy stress-confined irradiation conditions. Laser-induced pressure waves generated in the liver samples were detected by a wide-band acoustic transducer. Pressure wave amplitude, duration, and propagation time were analyzed after the experiments. The results and theoretical calculations have demonstrated that laser-induced optoacoustic signals from biological tissues with higher absorption coefficient are measurable at depth 5 times higher than penetration depth of radiation. Low acoustic attenuation (0.006 cm -1) for laser-induced pressure waves was detected. Feasibility of the proposed imaging to detect 3 mm 3 liver sample (tumor model) placed inside 80 mm-muscle tissue is demonstrated.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsRobert A. Lieberman, Halina Podbielska, Tuan Vo-Dinh
Pages84-90
Number of pages7
Volume2676
StatePublished - 1996
Externally publishedYes
EventBiomedical Sensing, Imaging, and Tracking Technologies I - San Jose, CA, USA
Duration: Jan 29 1996Jan 31 1996

Other

OtherBiomedical Sensing, Imaging, and Tracking Technologies I
CitySan Jose, CA, USA
Period1/29/961/31/96

Fingerprint

Tomography
tomography
Acoustics
Tissue
acoustics
Lasers
elastic waves
lasers
Photoacoustic effect
Experiments
liver
Liver
acoustic attenuation
absorptivity
muscles
Muscle
Acoustic transducers
chickens
signal detection
Signal detection

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Esenaliev, R., Oraevsky, A. A., Jacques, S. L., & Tittel, F. K. (1996). Laser opto-acoustic tomography for medical diagnostics: experiments with biological tissues. In R. A. Lieberman, H. Podbielska, & T. Vo-Dinh (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2676, pp. 84-90)

Laser opto-acoustic tomography for medical diagnostics : experiments with biological tissues. / Esenaliev, Rinat; Oraevsky, Alexander A.; Jacques, Steven L.; Tittel, Frank K.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Robert A. Lieberman; Halina Podbielska; Tuan Vo-Dinh. Vol. 2676 1996. p. 84-90.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Esenaliev, R, Oraevsky, AA, Jacques, SL & Tittel, FK 1996, Laser opto-acoustic tomography for medical diagnostics: experiments with biological tissues. in RA Lieberman, H Podbielska & T Vo-Dinh (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2676, pp. 84-90, Biomedical Sensing, Imaging, and Tracking Technologies I, San Jose, CA, USA, 1/29/96.
Esenaliev R, Oraevsky AA, Jacques SL, Tittel FK. Laser opto-acoustic tomography for medical diagnostics: experiments with biological tissues. In Lieberman RA, Podbielska H, Vo-Dinh T, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2676. 1996. p. 84-90
Esenaliev, Rinat ; Oraevsky, Alexander A. ; Jacques, Steven L. ; Tittel, Frank K. / Laser opto-acoustic tomography for medical diagnostics : experiments with biological tissues. Proceedings of SPIE - The International Society for Optical Engineering. editor / Robert A. Lieberman ; Halina Podbielska ; Tuan Vo-Dinh. Vol. 2676 1996. pp. 84-90
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