Laser optoacoustic tomography of layered tissues: Signal processing

Alexander A. Oraevsky, Rinat O. Esenaliev, Alexander Karabutov

Research output: Contribution to journalConference articlepeer-review

29 Scopus citations


Laser optoacoustic imaging experiments in biological tissues in vivo are presented along with the theoretical signal analysis procedure. The laser optoacoustic imaging system (LOIS) can operate in the reflection mode with emphasis on high z-axial (in-depth) resolution (up to 10-20 μm). Two examples of LOIS applications for non-invasive in vivo medical diagnostics are presented and discussed: (1) characterization of layered structure of port-wine stains, and (2) measurements of skin melanoma thickness. Potential miniaturization of LOIS for endoscopy applications is also discussed. The z-axial profiles of laser-induced pressure were shown to contain diagnostic information on location, dimensions and optical properties of tissue layers. Time-resolved signals detected by piezoelectric transducers were corrected for distortions such as diffraction and acoustic attenuation that occur upon pressure wave propagation in tissue. Wavelet transform applied to signals of laser-induced acoustic emission yielded high contrast pressure profiles with substantial signal-to-noise ratio.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1997
Externally publishedYes
EventProceedings of Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model and Human Studies II - San Jose, CA, United States
Duration: Feb 9 1997Feb 12 1997


  • Absorbed energy distribution
  • Conditions of temporal stress confinement
  • Imaging
  • Laser-induced pressure
  • Piezoelectric transducer
  • Transient stress

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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