Laser-tissue interaction during transmyocardial laser revascularization

E. Duco Jansen, Martin Frenz, Kamuran A. Kadipasaoglu, T. Joshua Pfefer, Hans J. Altermatt, Massoud Motamedi, Ashley J. Welch

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background. The clinical procedure known as transmyocardial revascularization has recently seen its renaissance. Unspite the promising preliminary clinical results, the associated mechanisms are subject to much discussion. This study is an attempt to unravel the basics of the interaction between 800-W CO2 laser radiation and biological tissue. Methods. Time-resolved flash photography was used to visualize the laser-induced channel formation in water and in vitro porcine myocardium. In addition, laser-induced pressures were measured. Light microscopy and birefringence microscopy were used to assess the histologic characteristics of laser-induced thermal damage. Results. The channel depth increased logarithmically with time (ie, with pulse duration) in water and porcine myocardium. Pressure measurements showed the occurrence of numerous small transients during the laser pulse, which corresponded with channel formation, as well as local and partial channel collapse during the laser pulse. Twenty millimeters of myocardium was perforated in 25 ms. Increasing the pulse duration had a small effect on the maximum transversable thickness, but histologic analysis showed that thermal damage around the crater increased with increasing pulse duration. Conclusions. Several basic aspects of the interaction of high-power CO2 laser radiation with myocardial tissue and tissue phantoms were studied in vitro. Although the goal of this study was not to unravel the mechanisms responsible for the beneficial effects of transmyocardial revascularization, it provided important information on the process of channel formation and collapse and tissue damage.

Original languageEnglish (US)
Pages (from-to)640-647
Number of pages8
JournalAnnals of Thoracic Surgery
Volume63
Issue number3
DOIs
StatePublished - Mar 1997
Externally publishedYes

Fingerprint

Transmyocardial Laser Revascularization
Lasers
Myocardium
Gas Lasers
Microscopy
Swine
Hot Temperature
Radiation
Birefringence
Pressure
Water
Photography
Light

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Jansen, E. D., Frenz, M., Kadipasaoglu, K. A., Pfefer, T. J., Altermatt, H. J., Motamedi, M., & Welch, A. J. (1997). Laser-tissue interaction during transmyocardial laser revascularization. Annals of Thoracic Surgery, 63(3), 640-647. https://doi.org/10.1016/S0003-4975(96)01143-5

Laser-tissue interaction during transmyocardial laser revascularization. / Jansen, E. Duco; Frenz, Martin; Kadipasaoglu, Kamuran A.; Pfefer, T. Joshua; Altermatt, Hans J.; Motamedi, Massoud; Welch, Ashley J.

In: Annals of Thoracic Surgery, Vol. 63, No. 3, 03.1997, p. 640-647.

Research output: Contribution to journalArticle

Jansen, ED, Frenz, M, Kadipasaoglu, KA, Pfefer, TJ, Altermatt, HJ, Motamedi, M & Welch, AJ 1997, 'Laser-tissue interaction during transmyocardial laser revascularization', Annals of Thoracic Surgery, vol. 63, no. 3, pp. 640-647. https://doi.org/10.1016/S0003-4975(96)01143-5
Jansen, E. Duco ; Frenz, Martin ; Kadipasaoglu, Kamuran A. ; Pfefer, T. Joshua ; Altermatt, Hans J. ; Motamedi, Massoud ; Welch, Ashley J. / Laser-tissue interaction during transmyocardial laser revascularization. In: Annals of Thoracic Surgery. 1997 ; Vol. 63, No. 3. pp. 640-647.
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