Late graft loss or death in pediatric liver transplantation

an analysis of the SPLIT database

K. A. Soltys, G. V. Mazariegos, R. H. Squires, R. K. Sindhi, R. Anand, Stephen Dunn, Jerome Manendez, Louise Flynn, Maureen Jonas, Laura Krawczuk, Marielle Christoff, Robert Kane, Harvey Solomon, Erin Phillips, Laurie Ferrer, Thomas Heffron, Jill DePaolo, Todd Pillen, Laurel Davis, John Bucuvalas & 147 others Fred Ryckman, Andre Hawkins, Gajra Arya, Michael R. Narkewicz, Ronald J. Sokol, Frederick Karrer, Cara Mark, Kathy Orban-Eller, Abhi Humar, Brenda Durand, Leslie Studenski, Elizabeth Rand, Kathleen Anderer, George Mazariegos, Nydia Chien, Lynn Seward, Paul Atkison, Jay Roden, Naveen Mittal, Lisa Cutright, Grzegorz Telega, Stacee Lerret, Estelle M. Alonso, Joan Lokar, Susan Kelly, Katie Neighbors, Walter S. Andrews, James Daniel, Vicki Fioravanti, Angela Tendick, Anne S. Lindblad, Ravinder Anand, Changhong Song, Karen Martz, Jeff Mitchell, Gladys Fraser, Nicole Hornbeak, Nirali Patel, Jianghang He, Annie Fecteau, Vicky Lee Ng, Maria De Angelis, Andreanne Benidir, Kathleen Schwarz, Paul Colombani, May Kay Alford, Michelle Felix, Robert Jurao, James Eason, John Eshun, Sandra L. Powell, Deborah Freese, Jody Weckwerth, Jean Greseth, Lori Young, Robert Fisher, Michael Akyeampong, Samuel So, William Berquist, Marcia Castillo, Annalie Bula, Sukru Emre, Benjamin Shneider, Nanda Kerkar, Salvador Cuellar, Saul Karpen, Jaymee Mayo, John Goss, Douglas Fishman, Val McLin, Beth Carter, Christine O'Mahony, Thomas Aloia, Donna Garner, Susan Gilmour, Bernadette Dodd, Norman Kneteman, Sue McDiarmid, Susan Fiest, Steven Lobritto, Lesley Smith, Patricia Harren, Kristin Maseda, Fernando Alvarez, Steven Martin, Carol Viau, Ross Shepherd, Jeffrey Lowell, Michelle Nadler, Joel Lavine, Ajai Khanna, Rosemarie Clawson, James Lopez, John Magee, Vicky Shieck, Jeffrey Fair, Steven Lichtman, Ken Andreoni, Joanne Prinzhorn, Valorie Buchholz, Simon Horslen, Melissa Young, Glenn Halff, Stacey Wallace, Joseph Tector, Joel Lim, Jean Molleston, Jean Pearson, Humberto Soriano, Kathleen Falkenstein, Andreas Tzakis, Tomoaki Kato, Debbie Weppler, Lisa Cooper, Monica Gonzalez, Alma Santiago, Munci Kalayoglu, Anthony D'Alessandro, Nissa Erickson, Robert Judo, Stuart Knechtle, Elizabeth Spaith, Regino Gonzalez-Peralta, Marcia Hodik, Stacia McCracken, Philip Rosenthal, Danusia Filipowski, Linda Book, Molly O'Gorman, Cynthia K. Kawai, Lacey Bruschke, Jennifer Kraus, Alan Langnas, Dean Antonson, Jean Botha, Wendy Grant, Debra Sudan, Debb Andersen, Beverly Fleckten, Kris Seipel, J. Michael Millis, Patricia Boone, Dev M. Desai, Sherri Javis, Peter Abt, Tomi Shisler, Cindy Mack

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.

Original languageEnglish (US)
Pages (from-to)2165-2171
Number of pages7
JournalAmerican Journal of Transplantation
Volume7
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Liver Transplantation
Databases
Pediatrics
Transplants
Mortality
Neoplasms
Multiple Organ Failure
Graft Survival
Reoperation
Allografts
Multivariate Analysis
Survival Rate
Steroids
Weights and Measures
Infection

Keywords

  • Immunosuppression
  • Infection
  • Long-term outcomes
  • Malignancy
  • Patient and graft survival
  • Pediatric liver transplantation

ASJC Scopus subject areas

  • Immunology

Cite this

Soltys, K. A., Mazariegos, G. V., Squires, R. H., Sindhi, R. K., Anand, R., Dunn, S., ... Mack, C. (2007). Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. American Journal of Transplantation, 7(9), 2165-2171. https://doi.org/10.1111/j.1600-6143.2007.01893.x

Late graft loss or death in pediatric liver transplantation : an analysis of the SPLIT database. / Soltys, K. A.; Mazariegos, G. V.; Squires, R. H.; Sindhi, R. K.; Anand, R.; Dunn, Stephen; Manendez, Jerome; Flynn, Louise; Jonas, Maureen; Krawczuk, Laura; Christoff, Marielle; Kane, Robert; Solomon, Harvey; Phillips, Erin; Ferrer, Laurie; Heffron, Thomas; DePaolo, Jill; Pillen, Todd; Davis, Laurel; Bucuvalas, John; Ryckman, Fred; Hawkins, Andre; Arya, Gajra; Narkewicz, Michael R.; Sokol, Ronald J.; Karrer, Frederick; Mark, Cara; Orban-Eller, Kathy; Humar, Abhi; Durand, Brenda; Studenski, Leslie; Rand, Elizabeth; Anderer, Kathleen; Mazariegos, George; Chien, Nydia; Seward, Lynn; Atkison, Paul; Roden, Jay; Mittal, Naveen; Cutright, Lisa; Telega, Grzegorz; Lerret, Stacee; Alonso, Estelle M.; Lokar, Joan; Kelly, Susan; Neighbors, Katie; Andrews, Walter S.; Daniel, James; Fioravanti, Vicki; Tendick, Angela; Lindblad, Anne S.; Anand, Ravinder; Song, Changhong; Martz, Karen; Mitchell, Jeff; Fraser, Gladys; Hornbeak, Nicole; Patel, Nirali; He, Jianghang; Fecteau, Annie; Ng, Vicky Lee; De Angelis, Maria; Benidir, Andreanne; Schwarz, Kathleen; Colombani, Paul; Alford, May Kay; Felix, Michelle; Jurao, Robert; Eason, James; Eshun, John; Powell, Sandra L.; Freese, Deborah; Weckwerth, Jody; Greseth, Jean; Young, Lori; Fisher, Robert; Akyeampong, Michael; So, Samuel; Berquist, William; Castillo, Marcia; Bula, Annalie; Emre, Sukru; Shneider, Benjamin; Kerkar, Nanda; Cuellar, Salvador; Karpen, Saul; Mayo, Jaymee; Goss, John; Fishman, Douglas; McLin, Val; Carter, Beth; O'Mahony, Christine; Aloia, Thomas; Garner, Donna; Gilmour, Susan; Dodd, Bernadette; Kneteman, Norman; McDiarmid, Sue; Fiest, Susan; Lobritto, Steven; Smith, Lesley; Harren, Patricia; Maseda, Kristin; Alvarez, Fernando; Martin, Steven; Viau, Carol; Shepherd, Ross; Lowell, Jeffrey; Nadler, Michelle; Lavine, Joel; Khanna, Ajai; Clawson, Rosemarie; Lopez, James; Magee, John; Shieck, Vicky; Fair, Jeffrey; Lichtman, Steven; Andreoni, Ken; Prinzhorn, Joanne; Buchholz, Valorie; Horslen, Simon; Young, Melissa; Halff, Glenn; Wallace, Stacey; Tector, Joseph; Lim, Joel; Molleston, Jean; Pearson, Jean; Soriano, Humberto; Falkenstein, Kathleen; Tzakis, Andreas; Kato, Tomoaki; Weppler, Debbie; Cooper, Lisa; Gonzalez, Monica; Santiago, Alma; Kalayoglu, Munci; D'Alessandro, Anthony; Erickson, Nissa; Judo, Robert; Knechtle, Stuart; Spaith, Elizabeth; Gonzalez-Peralta, Regino; Hodik, Marcia; McCracken, Stacia; Rosenthal, Philip; Filipowski, Danusia; Book, Linda; O'Gorman, Molly; Kawai, Cynthia K.; Bruschke, Lacey; Kraus, Jennifer; Langnas, Alan; Antonson, Dean; Botha, Jean; Grant, Wendy; Sudan, Debra; Andersen, Debb; Fleckten, Beverly; Seipel, Kris; Millis, J. Michael; Boone, Patricia; Desai, Dev M.; Javis, Sherri; Abt, Peter; Shisler, Tomi; Mack, Cindy.

In: American Journal of Transplantation, Vol. 7, No. 9, 09.2007, p. 2165-2171.

Research output: Contribution to journalArticle

Soltys, KA, Mazariegos, GV, Squires, RH, Sindhi, RK, Anand, R, Dunn, S, Manendez, J, Flynn, L, Jonas, M, Krawczuk, L, Christoff, M, Kane, R, Solomon, H, Phillips, E, Ferrer, L, Heffron, T, DePaolo, J, Pillen, T, Davis, L, Bucuvalas, J, Ryckman, F, Hawkins, A, Arya, G, Narkewicz, MR, Sokol, RJ, Karrer, F, Mark, C, Orban-Eller, K, Humar, A, Durand, B, Studenski, L, Rand, E, Anderer, K, Mazariegos, G, Chien, N, Seward, L, Atkison, P, Roden, J, Mittal, N, Cutright, L, Telega, G, Lerret, S, Alonso, EM, Lokar, J, Kelly, S, Neighbors, K, Andrews, WS, Daniel, J, Fioravanti, V, Tendick, A, Lindblad, AS, Anand, R, Song, C, Martz, K, Mitchell, J, Fraser, G, Hornbeak, N, Patel, N, He, J, Fecteau, A, Ng, VL, De Angelis, M, Benidir, A, Schwarz, K, Colombani, P, Alford, MK, Felix, M, Jurao, R, Eason, J, Eshun, J, Powell, SL, Freese, D, Weckwerth, J, Greseth, J, Young, L, Fisher, R, Akyeampong, M, So, S, Berquist, W, Castillo, M, Bula, A, Emre, S, Shneider, B, Kerkar, N, Cuellar, S, Karpen, S, Mayo, J, Goss, J, Fishman, D, McLin, V, Carter, B, O'Mahony, C, Aloia, T, Garner, D, Gilmour, S, Dodd, B, Kneteman, N, McDiarmid, S, Fiest, S, Lobritto, S, Smith, L, Harren, P, Maseda, K, Alvarez, F, Martin, S, Viau, C, Shepherd, R, Lowell, J, Nadler, M, Lavine, J, Khanna, A, Clawson, R, Lopez, J, Magee, J, Shieck, V, Fair, J, Lichtman, S, Andreoni, K, Prinzhorn, J, Buchholz, V, Horslen, S, Young, M, Halff, G, Wallace, S, Tector, J, Lim, J, Molleston, J, Pearson, J, Soriano, H, Falkenstein, K, Tzakis, A, Kato, T, Weppler, D, Cooper, L, Gonzalez, M, Santiago, A, Kalayoglu, M, D'Alessandro, A, Erickson, N, Judo, R, Knechtle, S, Spaith, E, Gonzalez-Peralta, R, Hodik, M, McCracken, S, Rosenthal, P, Filipowski, D, Book, L, O'Gorman, M, Kawai, CK, Bruschke, L, Kraus, J, Langnas, A, Antonson, D, Botha, J, Grant, W, Sudan, D, Andersen, D, Fleckten, B, Seipel, K, Millis, JM, Boone, P, Desai, DM, Javis, S, Abt, P, Shisler, T & Mack, C 2007, 'Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database', American Journal of Transplantation, vol. 7, no. 9, pp. 2165-2171. https://doi.org/10.1111/j.1600-6143.2007.01893.x
Soltys, K. A. ; Mazariegos, G. V. ; Squires, R. H. ; Sindhi, R. K. ; Anand, R. ; Dunn, Stephen ; Manendez, Jerome ; Flynn, Louise ; Jonas, Maureen ; Krawczuk, Laura ; Christoff, Marielle ; Kane, Robert ; Solomon, Harvey ; Phillips, Erin ; Ferrer, Laurie ; Heffron, Thomas ; DePaolo, Jill ; Pillen, Todd ; Davis, Laurel ; Bucuvalas, John ; Ryckman, Fred ; Hawkins, Andre ; Arya, Gajra ; Narkewicz, Michael R. ; Sokol, Ronald J. ; Karrer, Frederick ; Mark, Cara ; Orban-Eller, Kathy ; Humar, Abhi ; Durand, Brenda ; Studenski, Leslie ; Rand, Elizabeth ; Anderer, Kathleen ; Mazariegos, George ; Chien, Nydia ; Seward, Lynn ; Atkison, Paul ; Roden, Jay ; Mittal, Naveen ; Cutright, Lisa ; Telega, Grzegorz ; Lerret, Stacee ; Alonso, Estelle M. ; Lokar, Joan ; Kelly, Susan ; Neighbors, Katie ; Andrews, Walter S. ; Daniel, James ; Fioravanti, Vicki ; Tendick, Angela ; Lindblad, Anne S. ; Anand, Ravinder ; Song, Changhong ; Martz, Karen ; Mitchell, Jeff ; Fraser, Gladys ; Hornbeak, Nicole ; Patel, Nirali ; He, Jianghang ; Fecteau, Annie ; Ng, Vicky Lee ; De Angelis, Maria ; Benidir, Andreanne ; Schwarz, Kathleen ; Colombani, Paul ; Alford, May Kay ; Felix, Michelle ; Jurao, Robert ; Eason, James ; Eshun, John ; Powell, Sandra L. ; Freese, Deborah ; Weckwerth, Jody ; Greseth, Jean ; Young, Lori ; Fisher, Robert ; Akyeampong, Michael ; So, Samuel ; Berquist, William ; Castillo, Marcia ; Bula, Annalie ; Emre, Sukru ; Shneider, Benjamin ; Kerkar, Nanda ; Cuellar, Salvador ; Karpen, Saul ; Mayo, Jaymee ; Goss, John ; Fishman, Douglas ; McLin, Val ; Carter, Beth ; O'Mahony, Christine ; Aloia, Thomas ; Garner, Donna ; Gilmour, Susan ; Dodd, Bernadette ; Kneteman, Norman ; McDiarmid, Sue ; Fiest, Susan ; Lobritto, Steven ; Smith, Lesley ; Harren, Patricia ; Maseda, Kristin ; Alvarez, Fernando ; Martin, Steven ; Viau, Carol ; Shepherd, Ross ; Lowell, Jeffrey ; Nadler, Michelle ; Lavine, Joel ; Khanna, Ajai ; Clawson, Rosemarie ; Lopez, James ; Magee, John ; Shieck, Vicky ; Fair, Jeffrey ; Lichtman, Steven ; Andreoni, Ken ; Prinzhorn, Joanne ; Buchholz, Valorie ; Horslen, Simon ; Young, Melissa ; Halff, Glenn ; Wallace, Stacey ; Tector, Joseph ; Lim, Joel ; Molleston, Jean ; Pearson, Jean ; Soriano, Humberto ; Falkenstein, Kathleen ; Tzakis, Andreas ; Kato, Tomoaki ; Weppler, Debbie ; Cooper, Lisa ; Gonzalez, Monica ; Santiago, Alma ; Kalayoglu, Munci ; D'Alessandro, Anthony ; Erickson, Nissa ; Judo, Robert ; Knechtle, Stuart ; Spaith, Elizabeth ; Gonzalez-Peralta, Regino ; Hodik, Marcia ; McCracken, Stacia ; Rosenthal, Philip ; Filipowski, Danusia ; Book, Linda ; O'Gorman, Molly ; Kawai, Cynthia K. ; Bruschke, Lacey ; Kraus, Jennifer ; Langnas, Alan ; Antonson, Dean ; Botha, Jean ; Grant, Wendy ; Sudan, Debra ; Andersen, Debb ; Fleckten, Beverly ; Seipel, Kris ; Millis, J. Michael ; Boone, Patricia ; Desai, Dev M. ; Javis, Sherri ; Abt, Peter ; Shisler, Tomi ; Mack, Cindy. / Late graft loss or death in pediatric liver transplantation : an analysis of the SPLIT database. In: American Journal of Transplantation. 2007 ; Vol. 7, No. 9. pp. 2165-2171.
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title = "Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database",
abstract = "Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2{\%} and 89.2{\%}, respectively. Graft loss after the first year was caused by rejection in 49{\%} of the cases with sequelae of technical complications accounting for an additional 20{\%} of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8{\%} of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.",
keywords = "Immunosuppression, Infection, Long-term outcomes, Malignancy, Patient and graft survival, Pediatric liver transplantation",
author = "Soltys, {K. A.} and Mazariegos, {G. V.} and Squires, {R. H.} and Sindhi, {R. K.} and R. Anand and Stephen Dunn and Jerome Manendez and Louise Flynn and Maureen Jonas and Laura Krawczuk and Marielle Christoff and Robert Kane and Harvey Solomon and Erin Phillips and Laurie Ferrer and Thomas Heffron and Jill DePaolo and Todd Pillen and Laurel Davis and John Bucuvalas and Fred Ryckman and Andre Hawkins and Gajra Arya and Narkewicz, {Michael R.} and Sokol, {Ronald J.} and Frederick Karrer and Cara Mark and Kathy Orban-Eller and Abhi Humar and Brenda Durand and Leslie Studenski and Elizabeth Rand and Kathleen Anderer and George Mazariegos and Nydia Chien and Lynn Seward and Paul Atkison and Jay Roden and Naveen Mittal and Lisa Cutright and Grzegorz Telega and Stacee Lerret and Alonso, {Estelle M.} and Joan Lokar and Susan Kelly and Katie Neighbors and Andrews, {Walter S.} and James Daniel and Vicki Fioravanti and Angela Tendick and Lindblad, {Anne S.} and Ravinder Anand and Changhong Song and Karen Martz and Jeff Mitchell and Gladys Fraser and Nicole Hornbeak and Nirali Patel and Jianghang He and Annie Fecteau and Ng, {Vicky Lee} and {De Angelis}, Maria and Andreanne Benidir and Kathleen Schwarz and Paul Colombani and Alford, {May Kay} and Michelle Felix and Robert Jurao and James Eason and John Eshun and Powell, {Sandra L.} and Deborah Freese and Jody Weckwerth and Jean Greseth and Lori Young and Robert Fisher and Michael Akyeampong and Samuel So and William Berquist and Marcia Castillo and Annalie Bula and Sukru Emre and Benjamin Shneider and Nanda Kerkar and Salvador Cuellar and Saul Karpen and Jaymee Mayo and John Goss and Douglas Fishman and Val McLin and Beth Carter and Christine O'Mahony and Thomas Aloia and Donna Garner and Susan Gilmour and Bernadette Dodd and Norman Kneteman and Sue McDiarmid and Susan Fiest and Steven Lobritto and Lesley Smith and Patricia Harren and Kristin Maseda and Fernando Alvarez and Steven Martin and Carol Viau and Ross Shepherd and Jeffrey Lowell and Michelle Nadler and Joel Lavine and Ajai Khanna and Rosemarie Clawson and James Lopez and John Magee and Vicky Shieck and Jeffrey Fair and Steven Lichtman and Ken Andreoni and Joanne Prinzhorn and Valorie Buchholz and Simon Horslen and Melissa Young and Glenn Halff and Stacey Wallace and Joseph Tector and Joel Lim and Jean Molleston and Jean Pearson and Humberto Soriano and Kathleen Falkenstein and Andreas Tzakis and Tomoaki Kato and Debbie Weppler and Lisa Cooper and Monica Gonzalez and Alma Santiago and Munci Kalayoglu and Anthony D'Alessandro and Nissa Erickson and Robert Judo and Stuart Knechtle and Elizabeth Spaith and Regino Gonzalez-Peralta and Marcia Hodik and Stacia McCracken and Philip Rosenthal and Danusia Filipowski and Linda Book and Molly O'Gorman and Kawai, {Cynthia K.} and Lacey Bruschke and Jennifer Kraus and Alan Langnas and Dean Antonson and Jean Botha and Wendy Grant and Debra Sudan and Debb Andersen and Beverly Fleckten and Kris Seipel and Millis, {J. Michael} and Patricia Boone and Desai, {Dev M.} and Sherri Javis and Peter Abt and Tomi Shisler and Cindy Mack",
year = "2007",
month = "9",
doi = "10.1111/j.1600-6143.2007.01893.x",
language = "English (US)",
volume = "7",
pages = "2165--2171",
journal = "American Journal of Transplantation",
issn = "1600-6135",
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TY - JOUR

T1 - Late graft loss or death in pediatric liver transplantation

T2 - an analysis of the SPLIT database

AU - Soltys, K. A.

AU - Mazariegos, G. V.

AU - Squires, R. H.

AU - Sindhi, R. K.

AU - Anand, R.

AU - Dunn, Stephen

AU - Manendez, Jerome

AU - Flynn, Louise

AU - Jonas, Maureen

AU - Krawczuk, Laura

AU - Christoff, Marielle

AU - Kane, Robert

AU - Solomon, Harvey

AU - Phillips, Erin

AU - Ferrer, Laurie

AU - Heffron, Thomas

AU - DePaolo, Jill

AU - Pillen, Todd

AU - Davis, Laurel

AU - Bucuvalas, John

AU - Ryckman, Fred

AU - Hawkins, Andre

AU - Arya, Gajra

AU - Narkewicz, Michael R.

AU - Sokol, Ronald J.

AU - Karrer, Frederick

AU - Mark, Cara

AU - Orban-Eller, Kathy

AU - Humar, Abhi

AU - Durand, Brenda

AU - Studenski, Leslie

AU - Rand, Elizabeth

AU - Anderer, Kathleen

AU - Mazariegos, George

AU - Chien, Nydia

AU - Seward, Lynn

AU - Atkison, Paul

AU - Roden, Jay

AU - Mittal, Naveen

AU - Cutright, Lisa

AU - Telega, Grzegorz

AU - Lerret, Stacee

AU - Alonso, Estelle M.

AU - Lokar, Joan

AU - Kelly, Susan

AU - Neighbors, Katie

AU - Andrews, Walter S.

AU - Daniel, James

AU - Fioravanti, Vicki

AU - Tendick, Angela

AU - Lindblad, Anne S.

AU - Anand, Ravinder

AU - Song, Changhong

AU - Martz, Karen

AU - Mitchell, Jeff

AU - Fraser, Gladys

AU - Hornbeak, Nicole

AU - Patel, Nirali

AU - He, Jianghang

AU - Fecteau, Annie

AU - Ng, Vicky Lee

AU - De Angelis, Maria

AU - Benidir, Andreanne

AU - Schwarz, Kathleen

AU - Colombani, Paul

AU - Alford, May Kay

AU - Felix, Michelle

AU - Jurao, Robert

AU - Eason, James

AU - Eshun, John

AU - Powell, Sandra L.

AU - Freese, Deborah

AU - Weckwerth, Jody

AU - Greseth, Jean

AU - Young, Lori

AU - Fisher, Robert

AU - Akyeampong, Michael

AU - So, Samuel

AU - Berquist, William

AU - Castillo, Marcia

AU - Bula, Annalie

AU - Emre, Sukru

AU - Shneider, Benjamin

AU - Kerkar, Nanda

AU - Cuellar, Salvador

AU - Karpen, Saul

AU - Mayo, Jaymee

AU - Goss, John

AU - Fishman, Douglas

AU - McLin, Val

AU - Carter, Beth

AU - O'Mahony, Christine

AU - Aloia, Thomas

AU - Garner, Donna

AU - Gilmour, Susan

AU - Dodd, Bernadette

AU - Kneteman, Norman

AU - McDiarmid, Sue

AU - Fiest, Susan

AU - Lobritto, Steven

AU - Smith, Lesley

AU - Harren, Patricia

AU - Maseda, Kristin

AU - Alvarez, Fernando

AU - Martin, Steven

AU - Viau, Carol

AU - Shepherd, Ross

AU - Lowell, Jeffrey

AU - Nadler, Michelle

AU - Lavine, Joel

AU - Khanna, Ajai

AU - Clawson, Rosemarie

AU - Lopez, James

AU - Magee, John

AU - Shieck, Vicky

AU - Fair, Jeffrey

AU - Lichtman, Steven

AU - Andreoni, Ken

AU - Prinzhorn, Joanne

AU - Buchholz, Valorie

AU - Horslen, Simon

AU - Young, Melissa

AU - Halff, Glenn

AU - Wallace, Stacey

AU - Tector, Joseph

AU - Lim, Joel

AU - Molleston, Jean

AU - Pearson, Jean

AU - Soriano, Humberto

AU - Falkenstein, Kathleen

AU - Tzakis, Andreas

AU - Kato, Tomoaki

AU - Weppler, Debbie

AU - Cooper, Lisa

AU - Gonzalez, Monica

AU - Santiago, Alma

AU - Kalayoglu, Munci

AU - D'Alessandro, Anthony

AU - Erickson, Nissa

AU - Judo, Robert

AU - Knechtle, Stuart

AU - Spaith, Elizabeth

AU - Gonzalez-Peralta, Regino

AU - Hodik, Marcia

AU - McCracken, Stacia

AU - Rosenthal, Philip

AU - Filipowski, Danusia

AU - Book, Linda

AU - O'Gorman, Molly

AU - Kawai, Cynthia K.

AU - Bruschke, Lacey

AU - Kraus, Jennifer

AU - Langnas, Alan

AU - Antonson, Dean

AU - Botha, Jean

AU - Grant, Wendy

AU - Sudan, Debra

AU - Andersen, Debb

AU - Fleckten, Beverly

AU - Seipel, Kris

AU - Millis, J. Michael

AU - Boone, Patricia

AU - Desai, Dev M.

AU - Javis, Sherri

AU - Abt, Peter

AU - Shisler, Tomi

AU - Mack, Cindy

PY - 2007/9

Y1 - 2007/9

N2 - Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.

AB - Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.

KW - Immunosuppression

KW - Infection

KW - Long-term outcomes

KW - Malignancy

KW - Patient and graft survival

KW - Pediatric liver transplantation

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U2 - 10.1111/j.1600-6143.2007.01893.x

DO - 10.1111/j.1600-6143.2007.01893.x

M3 - Article

VL - 7

SP - 2165

EP - 2171

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 9

ER -