Latent expression of p53 mutations and radiation-induced mammary cancer

C. S. Selvanayagam, C. M. Davis, Michael Cornforth, R. L. Ullrich

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Abstract

EF42 is a clonally derived preneoplastic cell lineage from irradiated mouse mammary tissue, which becomes neoplastic with time in vitro or in vivo. We now report that multiple mutations in p53 occur before the acquisition of the neoplastic phenotype. The selective expansion of mutant cells is accompanied by loss of heterozygosity at the p53 locus and c-myc amplification. Although p53 mutations represent critical early events, our data argue these mutations were not directly induced by radiation but arose in the progeny of irradiated cells several cell generations later. The data are consistent with a multistep model of carcinogenesis that identifies genomic instability as the earliest step.

Original languageEnglish (US)
Pages (from-to)3310-3317
Number of pages8
JournalCancer Research
Volume55
Issue number15
StatePublished - 1995

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Selvanayagam, C. S., Davis, C. M., Cornforth, M., & Ullrich, R. L. (1995). Latent expression of p53 mutations and radiation-induced mammary cancer. Cancer Research, 55(15), 3310-3317.