Lateral diffusion in biological membranes. A normal-mode analysis of diffusion on a spherical surface

D. E. Koppel; M. P. Sheetz; M. Schindler

doi:10.1016/S0006-3495(80)85087-9

Lateral diffusion in biological membranes. A normal-mode analysis of diffusion on a spherical surface

D. E. Koppel, M. P. Sheetz, M. Schindler

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37 Scopus citations

Abstract

A new approach is described for the analysis of lateral diffusion in biological membranes. It is shown that a suitably defined first moment of the concentration distribution on a spherical surface decays as a single exponential with a relaxation rate proportional to the diffusion coefficient and inversely proportional to the square of the radius of the sphere. The approach is illustrated with an example of fluorescence redistribution after photobleaching of membrane proteins in a spectrin-deficient spherocytic mouse erythrocyte membrane.

Original language	English (US)
Pages (from-to)	187-192
Number of pages	6
Journal	Biophysical journal
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/S0006-3495(80)85087-9
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Biophysics

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10.1016/S0006-3495(80)85087-9

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abstract = "A new approach is described for the analysis of lateral diffusion in biological membranes. It is shown that a suitably defined first moment of the concentration distribution on a spherical surface decays as a single exponential with a relaxation rate proportional to the diffusion coefficient and inversely proportional to the square of the radius of the sphere. The approach is illustrated with an example of fluorescence redistribution after photobleaching of membrane proteins in a spectrin-deficient spherocytic mouse erythrocyte membrane.",

author = "Koppel, {D. E.} and Sheetz, {M. P.} and M. Schindler",

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AU - Koppel, D. E.

AU - Sheetz, M. P.

AU - Schindler, M.

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Y1 - 1980

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AB - A new approach is described for the analysis of lateral diffusion in biological membranes. It is shown that a suitably defined first moment of the concentration distribution on a spherical surface decays as a single exponential with a relaxation rate proportional to the diffusion coefficient and inversely proportional to the square of the radius of the sphere. The approach is illustrated with an example of fluorescence redistribution after photobleaching of membrane proteins in a spectrin-deficient spherocytic mouse erythrocyte membrane.

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ER -

Lateral diffusion in biological membranes. A normal-mode analysis of diffusion on a spherical surface

Abstract

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