Lateral diffusion in biological membranes. A normal-mode analysis of diffusion on a spherical surface

D. E. Koppel, Michael Sheetz, M. Schindler

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A new approach is described for the analysis of lateral diffusion in biological membranes. It is shown that a suitably defined first moment of the concentration distribution on a spherical surface decays as a single exponential with a relaxation rate proportional to the diffusion coefficient and inversely proportional to the square of the radius of the sphere. The approach is illustrated with an example of fluorescence redistribution after photobleaching of membrane proteins in a spectrin-deficient spherocytic mouse erythrocyte membrane.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalBiophysical Journal
Volume30
Issue number1
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Photobleaching
Spectrin
Membranes
Erythrocyte Membrane
Membrane Proteins
Fluorescence

ASJC Scopus subject areas

  • Biophysics

Cite this

Lateral diffusion in biological membranes. A normal-mode analysis of diffusion on a spherical surface. / Koppel, D. E.; Sheetz, Michael; Schindler, M.

In: Biophysical Journal, Vol. 30, No. 1, 01.01.1980, p. 187-192.

Research output: Contribution to journalArticle

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