Lateral membrane waves constitute a universal dynamic pattern of motile cells

Hans Günther Döbereiner, Benjamin J. Dubin-Thaler, Jake M. Hofman, Harry S. Xenias, Tasha N. Sims, Grégory Giannone, Michael L. Dustin, Chris H. Wiggins, Michael Sheetz

Research output: Contribution to journalArticle

124 Scopus citations

Abstract

We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cells from fruit flies. Despite having different functions and being from multiple phyla, these cell types share a common spatiotemporal pattern in their normal membrane velocity; we show that protrusion and retraction events are organized in lateral waves along the cell membrane. These wave patterns indicate both spatial and temporal long-range periodic correlations of the actomyosin gel.

Original languageEnglish (US)
Article number038102
JournalPhysical Review Letters
Volume97
Issue number3
DOIs
StatePublished - Jul 27 2006
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Döbereiner, H. G., Dubin-Thaler, B. J., Hofman, J. M., Xenias, H. S., Sims, T. N., Giannone, G., Dustin, M. L., Wiggins, C. H., & Sheetz, M. (2006). Lateral membrane waves constitute a universal dynamic pattern of motile cells. Physical Review Letters, 97(3), [038102]. https://doi.org/10.1103/PhysRevLett.97.038102