Lead intoxication among demolition workers: the effect of lead on the hepatic cytochrome P-450 system in humans

A. Fischbein, A. P. Alvares, Karl Anderson, S. Sassa, A. Kappas

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Overt clinical disease from undue lead exposure has become a relatively rare phenomenon in adult populations. However, exposure situations that may result in subclinical disease are not uncommon in various occupational settings. Five demolition workers, dismantling an old iron structure covered with lead-content paint, were studied. The use of cutting torches resulted in lead fumes, with significant exposure, albeit without gross 'lead poisoning'. All five workers showed biochemical manifestations of chronic lead intoxication - that is, elevated blood level, inhibition of δ-aminolevulinic acid dehydratase (ALA-D), and elevated erythrocytic protoporphyrin concentration (PROTO). The effect of lead on the biosynthesis of heme was assessed by investigating the functional capacity of the cytochrome P-450 system of the liver, through drug metabolism studies. The plasma elimination rates (half-lives) of antipyrine and phenylbutazone - drugs primarily metabolized by the hemeprotein P-450 dependent hepatic microsomal enzyme system - were measured before and after chelation therapy. Prior to chelation therapy all half-lives were within the normal range. A slight decrease in the half-life of antipyrine was found after treatment. These studies show that chronic exposure to lead has only a minimal effect on hepatic cytochrome P-450 dependent enzymatic activities in adult males.

Original languageEnglish (US)
Pages (from-to)431-437
Number of pages7
JournalJournal of Toxicology and Environmental Health
Volume3
Issue number3
StatePublished - 1977
Externally publishedYes

Fingerprint

Demolition
Cytochrome P-450 Enzyme System
Lead
Liver
Chelation Therapy
Antipyrine
Chelation
Industrial poisons
Porphobilinogen Synthase
Hemeproteins
Phenylbutazone
Lead Poisoning
Fumes
Paint
Biosynthesis
Heme
Metabolism
Pharmaceutical Preparations
Half-Life
Reference Values

ASJC Scopus subject areas

  • Toxicology
  • Pollution

Cite this

Lead intoxication among demolition workers : the effect of lead on the hepatic cytochrome P-450 system in humans. / Fischbein, A.; Alvares, A. P.; Anderson, Karl; Sassa, S.; Kappas, A.

In: Journal of Toxicology and Environmental Health, Vol. 3, No. 3, 1977, p. 431-437.

Research output: Contribution to journalArticle

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