Left atrial appendage occlusion for stroke prevention in nonvalvular atrial fibrillation

Fareed Moses S. Collado, Claudia M.Lama von Buchwald, Christina K. Anderson, Nidhi Madan, Hussam S. Suradi, Henry D. Huang, Hani Jneid, Clifford J. Kavinsky

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The majority of embolic strokes in patients with nonvalvular atrial fibrillation are caused by thrombi in the left atrial appendage. It is projected that strokes related to atrial fibrillation will markedly increase in the future unless effective mitiga-tion strategies are implemented. Systemic anticoagulation has been known to be highly effective in reducing stroke risk in patients with atrial fibrillation. However, bleeding complications and nonadherence are barriers to effective anticoagulation therapy. Surgical and percutaneous left atrial appendage occlusion devices are nonpharmacologic strategies to mitigate the challenges of drug therapy. We present a contemporary review of left atrial appendage occlusion for stroke prevention in nonvalvular atrial fibrillation. A thorough review of the history of surgical and percutaneous left atrial appendage occlusion devices, recent trials, and US Food and Drug Administration milestones of current left atrial appendage occlusion devices are discussed.

Original languageEnglish (US)
Article numbere022274
JournalJournal of the American Heart Association
Volume10
Issue number21
DOIs
StatePublished - Nov 2 2021
Externally publishedYes

Keywords

  • Atrial fibrillation
  • Left atrial appendage
  • Left atrial appendage occlusion
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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