Left atrial pressure-clamp servomechanism demonstrates LV suction in canine hearts with normal mitral valves

N. B. Ingels, G. T. Daughters, S. D. Nikolic, Abelardo DeAnda, M. R. Moon, A. F. Bolger, M. Komeda, G. C. Derby, E. L. Yellin, D. C. Miller

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A novel technique is presented to study suction of the in situ left ventricle in open-chest experimental animals without requiring cardiopulmonary bypass or disturbing the native mitral valvular apparatus. In 17 dogs, left ventricular pressure (LVP) and left atrial pressure (LAP) were measured, the left atrium was cannulated and connected to a servo pump, and LAP was controlled to a setpoint near 0 mmHg by withdrawing blood from the left atrium. Heart rate [103 ± 17 (SD) min-1], peak pressure (100 ± 13 mmHg), minimum pressure (1.4 ± 0.8 mmHg), and maximum rate of change of pressure with respect to time during isovolumic contraction and relaxation (2,506 ± 775 and -1,761 ± 855 mmHg/s, respectively) were normal. Servo control of LAP was possible to ±1 mmHg. LV suction was demonstrated in each heart (mean negative LVP -2.3 ± 1.1 mmHg; P <0.0001). This new technique demonstrates that the left ventricle can generate negative diastolic suction pressures when examined in vivo and in situ with an undisturbed mitral valve and physiologically normal preload and afterload. This adds to a growing body of evidence that, under appropriate circumstances, the heart can suck blood into itself and thereby aid in its own filling.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume267
Issue number1 36-1
StatePublished - 1994
Externally publishedYes

Fingerprint

Atrial Pressure
Suction
Mitral Valve
Canidae
Ventricular Pressure
Heart Atria
Pressure
Heart Ventricles
Cardiopulmonary Bypass
Thorax
Heart Rate
Dogs
Blood Pressure

Keywords

  • left atrial pressure control
  • left atrium
  • left ventricle
  • left ventricular diastolic filling

ASJC Scopus subject areas

  • Physiology

Cite this

Left atrial pressure-clamp servomechanism demonstrates LV suction in canine hearts with normal mitral valves. / Ingels, N. B.; Daughters, G. T.; Nikolic, S. D.; DeAnda, Abelardo; Moon, M. R.; Bolger, A. F.; Komeda, M.; Derby, G. C.; Yellin, E. L.; Miller, D. C.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 267, No. 1 36-1, 1994.

Research output: Contribution to journalArticle

Ingels, NB, Daughters, GT, Nikolic, SD, DeAnda, A, Moon, MR, Bolger, AF, Komeda, M, Derby, GC, Yellin, EL & Miller, DC 1994, 'Left atrial pressure-clamp servomechanism demonstrates LV suction in canine hearts with normal mitral valves', American Journal of Physiology - Heart and Circulatory Physiology, vol. 267, no. 1 36-1.
Ingels, N. B. ; Daughters, G. T. ; Nikolic, S. D. ; DeAnda, Abelardo ; Moon, M. R. ; Bolger, A. F. ; Komeda, M. ; Derby, G. C. ; Yellin, E. L. ; Miller, D. C. / Left atrial pressure-clamp servomechanism demonstrates LV suction in canine hearts with normal mitral valves. In: American Journal of Physiology - Heart and Circulatory Physiology. 1994 ; Vol. 267, No. 1 36-1.
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