Left ventricular diastolic suction with zero left atrial pressure in open-chest dogs

Neil B. Ingels, George T. Daughters, Srdjan D. Nikolic, Abe DeAnda, Marc R. Moon, Ann F. Bolger, Masashi Komeda, Geraldine C. Derby, Edward L. Yellin, D. Craig Miller

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We investigated left ventricular (LV) diastolic volume changes (suction inflows) with left atrial pressure (LAP) clamped to ambient pressure in six open-chest, anesthetized dogs. The left atrium was cannulated and connected to a servo pump, and LAP was clamped to a set point near 0 mmHg for four beats by withdrawing blood. LAP averaged 5.88 ± 1.44 mmHg before the clamp and fell to 0.74 ± 0.61 mmHg (P < 0.0001) after the clamp. During the first clamped beat a transmitral pressure gradient of 1.0 ± 0.6 mmHg was observed, resulting in LV filling of 2.6 ± 1.8 ml. Subsequent beats developed suction-driven (mean negative LV pressure: -1.5 ± 1.3 mmHg; P < 0.005 vs. zero) LV filling of 4.5 ± 2.8 ml/beat with a peak transmitral pressure gradient of 1.7 ± 0.6 mmHg. These data are consistent with the hypothesis that LV suction can be an important filling mechanism under conditions in which LV end-systolic volume is reduced, e.g., reduced filling pressures, high heart rates, exercise, or increased inotropic drive.

Original languageEnglish (US)
Pages (from-to)H1217-H1224
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume270
Issue number4 39-4
DOIs
StatePublished - Jan 1 1996

Keywords

  • Left atrial pressure clamp
  • Left atrium
  • Left ventricle
  • Left ventricular diastolic filling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Ingels, N. B., Daughters, G. T., Nikolic, S. D., DeAnda, A., Moon, M. R., Bolger, A. F., Komeda, M., Derby, G. C., Yellin, E. L., & Miller, D. C. (1996). Left ventricular diastolic suction with zero left atrial pressure in open-chest dogs. American Journal of Physiology - Heart and Circulatory Physiology, 270(4 39-4), H1217-H1224. https://doi.org/10.1152/ajpheart.1996.270.4.h1217