Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure

Pál Pacher, Jon G. Mabley, Lucas Liaudet, Oleg V. Evgenov, Anita Marton, György Haskó, Márk Kollai, Csaba Szabó

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    Abstract

    Aging is associated with profound changes in the structure and function of the heart. A fundamental understanding of these processes, using relevant animal models, is required for effective prevention and treatment of cardiovascular disease in the elderly. Here, we studied cardiac performance in 4- to 5-mo-old (young) and 24- to 26-mo-old (old) Fischer 344 male rats using the Millar pressure-volume (P-V) conductance catheter system. We evaluated systolic and diastolic function in vivo at different preloads, including preload recruitable stroke work (PRSW), maximal slope of the systolic pressure increment (+dP/dt), and its relation to end-diastolic volume (+dP/dt-EDV) as well as the time constant of left ventricular pressure decay, as an index of relaxation. The slope of the end-diastolic P-V relation (EDPVR), an index of left ventricular stiffness, was also calculated. Aging was associated with decrease in left ventricular systolic pressure, +dP/dt, maximal slope of the diastolic pressure decrement, +dP/dt-EDV, PRSW, ejection fraction, stroke volume, cardiac and stroke work indexes, and efficiency. In contrast, total peripheral resistance, left ventricular end-diastolic volume, left ventricular end-diastolic pressure, and EDPVR were greater in aging than in young animals. Taken together, these data suggest that advanced aging is characterized by decreased systolic performance accompanied by delayed relaxation and increased diastolic stiffness of the heart in male Fischer 344 rats. P-V analysis is a sensitive method to determine cardiac function in rats.

    Original languageEnglish (US)
    Pages (from-to)H2132-H2137
    JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
    Volume287
    Issue number5 56-5
    DOIs
    StatePublished - Nov 1 2004

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    Keywords

    • Diastolic dysfunction
    • Systolic dysfunction

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Cite this

    Pacher, P., Mabley, J. G., Liaudet, L., Evgenov, O. V., Marton, A., Haskó, G., Kollai, M., & Szabó, C. (2004). Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure. American Journal of Physiology - Heart and Circulatory Physiology, 287(5 56-5), H2132-H2137. https://doi.org/10.1152/ajpheart.00405.2004