Leishmania

P. C. Melby, B. L. Travi, E. Yaneth Osorio

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Leishmania are dimorphic intracellular protozoan parasites of vertebrates that are transmitted by phlebotomine sand flies. Multiple Leishmania spp. cause diverse human disease, which includes cutaneous lesions, destructive mucosal lesions, and severe visceral disease. The parasite’s complex life cycle includes cellular and biochemical changes that are required for transition from the sand fly to vertebrate host. Leishmania have novel mechanisms of RNA processing and uncommon mechanisms of gene regulation. Cellular immune mechanisms are protective, but the parasite subverts immune function to promote intracellular survival. Treatment of leishmaniasis is challenging, so prevention is critical. Development of an effective vaccine may be possible.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Microbiology
PublisherElsevier
Pages769-779
Number of pages11
ISBN (Electronic)9780128117378
ISBN (Print)9780128117361
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cellular immunity
  • Kinetoplastida
  • Leishmania
  • Leishmaniasis
  • Macrophage
  • Phagocytosis
  • Phagolysosome
  • RNA editing
  • Sand fly
  • T cells
  • Trans-splicing
  • Trypnosomatidae

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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  • Cite this

    Melby, P. C., Travi, B. L., & Yaneth Osorio, E. (2019). Leishmania. In Encyclopedia of Microbiology (pp. 769-779). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.02473-9