Leishmania amastigote target antigens

The challenge of a stealthy intracellular parasite

Diane McMahon-Pratt, Peter E. Kima, Lynn Soong

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The development of a defined molecular vaccine against leishmaniasis involves the determination of candidate molecules that elicit protection against infection. As the amastigote stage is the developmental form found in the infected mammalian host, molecules specific to or upregulated in this stage represent potential antigenic vaccine targets. Diane McMahon-Pratt, Peter Kima and Lynn Soong summarize experiments which indicate that immunization with molecules upregulated in the amastigote stage can provide effective protection against infection. In the immunized host, both CD4+ and CD8+ T cells appear to be crucial to protection. Studies of antigen presentation of Leishmania-infected macrophages indicate that the amastigote stage can sequester endogenous leishmanial antigen from the major histocompatability complex (MHC) class II presentation pathway. However, evidence indicates that MHC class I presentation may be sustained in the infected macrophage. The effect of these findings on the design of a leishmanial vaccine are considered.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalParasitology Today
Volume14
Issue number1
DOIs
StatePublished - Jan 1998
Externally publishedYes

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Leishmania
Parasites
Vaccines
Macrophages
Antigens
Synthetic Vaccines
Leishmaniasis
Antigen Presentation
Infection
Immunization
T-Lymphocytes
Ethinyl estradiol drug combination Cyproterone acetate

ASJC Scopus subject areas

  • Parasitology

Cite this

Leishmania amastigote target antigens : The challenge of a stealthy intracellular parasite. / McMahon-Pratt, Diane; Kima, Peter E.; Soong, Lynn.

In: Parasitology Today, Vol. 14, No. 1, 01.1998, p. 31-34.

Research output: Contribution to journalArticle

McMahon-Pratt, Diane ; Kima, Peter E. ; Soong, Lynn. / Leishmania amastigote target antigens : The challenge of a stealthy intracellular parasite. In: Parasitology Today. 1998 ; Vol. 14, No. 1. pp. 31-34.
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