Leishmania (Viannia) braziliensis infection in two Colombian dogs

a note on infectivity for sand flies and response to treatment.

Bruno Travi, Carlos Javier Tabares, Horacio Cadena

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

INTRODUCTION: Although canine cutaneous leishmaniasis has been reported in several foci of South America, no published information from Colombia is available. OBJECTIVE: We report on two cases found in the Pacific coast region of this country, which presented as a single scrotal ulcer in one dog, and two ulcers on the external surface of the ear in a second dog. MATERIALS AND METHODS: Parasites were isolated by culture in Senekjie's culture medium and identified using monoclonal antibodies. The capacity of these dogs to transmit the parasites to sand fly vectors (Lutzomyia trapidoi, Lutzomyia gomezi, Lutzomyia longipalpis, Lutzomyia youngi) was tested by allowing the flies to feed on the lesion borders. RESULTS: Both isolates were identified as Leishmania (Viannia) braziliensis. No infections were detected upon dissection of engorged flies. A single peri-and sub-lesional injection of 1-2 ml of pentavalent antimony in the dog with ear lesions resulted in clinical cure 6 weeks post-treatment. CONCLUSIONS: These observations suggest that although dogs are susceptible to L. braziliensis, their reservoir competence could be low. However, if further studies indicate that canines are capable reservoir hosts of L. Viannia spp., the local treatment of lesions could become a feasible approach to diminish the risk of human infection in the peridomestic setting, without sacrificing infected dogs.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalBiomédica : revista del Instituto Nacional de Salud
Volume26 Suppl 1
StatePublished - Oct 2006
Externally publishedYes

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Leishmania braziliensis
Psychodidae
Sand
Dogs
Antimony
Dissection
Infection
Coastal zones
Culture Media
Monoclonal Antibodies
Diptera
Ulcer
Canidae
Parasites
Therapeutics
External Ear
Cutaneous Leishmaniasis
Colombia
South America
Mental Competency

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Leishmania (Viannia) braziliensis infection in two Colombian dogs : a note on infectivity for sand flies and response to treatment. / Travi, Bruno; Tabares, Carlos Javier; Cadena, Horacio.

In: Biomédica : revista del Instituto Nacional de Salud, Vol. 26 Suppl 1, 10.2006, p. 249-253.

Research output: Contribution to journalArticle

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abstract = "INTRODUCTION: Although canine cutaneous leishmaniasis has been reported in several foci of South America, no published information from Colombia is available. OBJECTIVE: We report on two cases found in the Pacific coast region of this country, which presented as a single scrotal ulcer in one dog, and two ulcers on the external surface of the ear in a second dog. MATERIALS AND METHODS: Parasites were isolated by culture in Senekjie's culture medium and identified using monoclonal antibodies. The capacity of these dogs to transmit the parasites to sand fly vectors (Lutzomyia trapidoi, Lutzomyia gomezi, Lutzomyia longipalpis, Lutzomyia youngi) was tested by allowing the flies to feed on the lesion borders. RESULTS: Both isolates were identified as Leishmania (Viannia) braziliensis. No infections were detected upon dissection of engorged flies. A single peri-and sub-lesional injection of 1-2 ml of pentavalent antimony in the dog with ear lesions resulted in clinical cure 6 weeks post-treatment. CONCLUSIONS: These observations suggest that although dogs are susceptible to L. braziliensis, their reservoir competence could be low. However, if further studies indicate that canines are capable reservoir hosts of L. Viannia spp., the local treatment of lesions could become a feasible approach to diminish the risk of human infection in the peridomestic setting, without sacrificing infected dogs.",
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AB - INTRODUCTION: Although canine cutaneous leishmaniasis has been reported in several foci of South America, no published information from Colombia is available. OBJECTIVE: We report on two cases found in the Pacific coast region of this country, which presented as a single scrotal ulcer in one dog, and two ulcers on the external surface of the ear in a second dog. MATERIALS AND METHODS: Parasites were isolated by culture in Senekjie's culture medium and identified using monoclonal antibodies. The capacity of these dogs to transmit the parasites to sand fly vectors (Lutzomyia trapidoi, Lutzomyia gomezi, Lutzomyia longipalpis, Lutzomyia youngi) was tested by allowing the flies to feed on the lesion borders. RESULTS: Both isolates were identified as Leishmania (Viannia) braziliensis. No infections were detected upon dissection of engorged flies. A single peri-and sub-lesional injection of 1-2 ml of pentavalent antimony in the dog with ear lesions resulted in clinical cure 6 weeks post-treatment. CONCLUSIONS: These observations suggest that although dogs are susceptible to L. braziliensis, their reservoir competence could be low. However, if further studies indicate that canines are capable reservoir hosts of L. Viannia spp., the local treatment of lesions could become a feasible approach to diminish the risk of human infection in the peridomestic setting, without sacrificing infected dogs.

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