Leitmotifs in the biochemistry of LTP induction

Amplification, integration and coordination

Kelly Dineley, Edwin J. Weeber, Coleen Atkins, J. Paige Adams, Anne E. Anderson, J. David Sweatt

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Hippocampal long-term potentiation (LTP) is a robust and long-lasting form of synaptic plasticity that is the leading candidate for a cellular mechanism contributing to mammalian learning and memory. Investigations over the past decade have revealed that the biochemistry of LTP induction involves mechanisms of great subtlety and complexity. This review highlights themes that have emerged as a result of our increased knowledge of the signal transduction pathways involved in the induction of NMDA receptor-dependent LTP in area CA1 of the hippocampus. Among these themes are signal amplification, signal integration and signal coordination. Here we use these themes as an organizing context for reviewing the profusion of signaling mechanisms involved in the induction of LTP.

Original languageEnglish (US)
Pages (from-to)961-971
Number of pages11
JournalJournal of Neurochemistry
Volume77
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

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Signal transduction
Biochemistry
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Plasticity
Amplification
Data storage equipment
Neuronal Plasticity
Signal Transduction
Hippocampus
Learning

Keywords

  • CA1
  • Excitability
  • Kinase
  • Long-term potentiation
  • Memory
  • Review

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Leitmotifs in the biochemistry of LTP induction : Amplification, integration and coordination. / Dineley, Kelly; Weeber, Edwin J.; Atkins, Coleen; Adams, J. Paige; Anderson, Anne E.; Sweatt, J. David.

In: Journal of Neurochemistry, Vol. 77, No. 4, 2001, p. 961-971.

Research output: Contribution to journalArticle

Dineley, Kelly ; Weeber, Edwin J. ; Atkins, Coleen ; Adams, J. Paige ; Anderson, Anne E. ; Sweatt, J. David. / Leitmotifs in the biochemistry of LTP induction : Amplification, integration and coordination. In: Journal of Neurochemistry. 2001 ; Vol. 77, No. 4. pp. 961-971.
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