Lens glutathione depletion of 1-chloro-2,4-dinitrobenzene and oxidative stress

Satish K. Srivastava; Naseem H. Ansari; Yogesh C. Awasthi

doi:10.3109/02713688408997192

Lens glutathione depletion of 1-chloro-2,4-dinitrobenzene and oxidative stress

Satish K. Srivastava, Naseem H. Ansari, Yogesh C. Awasthi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Rat lenses in which all the glutathione has been conjugated with 1-chloro-2,4-dinitrobenzene remain apparently transparent for extended periods of time (up to 24 hours), but are more susceptible to oxidative damage by oxidants such as superoxide anions and hydrogen peroxide. Reduced glutathione has an additional role of detoxification of xenobiotics to form the corresponding mercapturic acids and protection of lens by conjugating the xenobiotics which could be transported out of the lens. The GSH-xenobiotic conjugate transport system is probably shared by GSSG.

Original language	English (US)
Pages (from-to)	117-119
Number of pages	3
Journal	Current Eye Research
Volume	3
Issue number	1
DOIs	https://doi.org/10.3109/02713688408997192
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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abstract = "Rat lenses in which all the glutathione has been conjugated with 1-chloro-2,4-dinitrobenzene remain apparently transparent for extended periods of time (up to 24 hours), but are more susceptible to oxidative damage by oxidants such as superoxide anions and hydrogen peroxide. Reduced glutathione has an additional role of detoxification of xenobiotics to form the corresponding mercapturic acids and protection of lens by conjugating the xenobiotics which could be transported out of the lens. The GSH-xenobiotic conjugate transport system is probably shared by GSSG.",

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year = "1984",

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AU - Ansari, Naseem H.

AU - Awasthi, Yogesh C.

PY - 1984

Y1 - 1984

N2 - Rat lenses in which all the glutathione has been conjugated with 1-chloro-2,4-dinitrobenzene remain apparently transparent for extended periods of time (up to 24 hours), but are more susceptible to oxidative damage by oxidants such as superoxide anions and hydrogen peroxide. Reduced glutathione has an additional role of detoxification of xenobiotics to form the corresponding mercapturic acids and protection of lens by conjugating the xenobiotics which could be transported out of the lens. The GSH-xenobiotic conjugate transport system is probably shared by GSSG.

AB - Rat lenses in which all the glutathione has been conjugated with 1-chloro-2,4-dinitrobenzene remain apparently transparent for extended periods of time (up to 24 hours), but are more susceptible to oxidative damage by oxidants such as superoxide anions and hydrogen peroxide. Reduced glutathione has an additional role of detoxification of xenobiotics to form the corresponding mercapturic acids and protection of lens by conjugating the xenobiotics which could be transported out of the lens. The GSH-xenobiotic conjugate transport system is probably shared by GSSG.

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Lens glutathione depletion of 1-chloro-2,4-dinitrobenzene and oxidative stress

Abstract

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