Lens glutathione depletion of 1-chloro-2,4-dinitrobenzene and oxidative stress

Satish Srivastava, Naseem Ansari, Yogesh C. Awasthi

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Rat lenses in which all the glutathione has been conjugated with 1-chloro-2,4-dinitrobenzene remain apparently transparent for extended periods of time (up to 24 hours), but are more susceptible to oxidative damage by oxidants such as superoxide anions and hydrogen peroxide. Reduced glutathione has an additional role of detoxification of xenobiotics to form the corresponding mercapturic acids and protection of lens by conjugating the xenobiotics which could be transported out of the lens. The GSH-xenobiotic conjugate transport system is probably shared by GSSG.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalCurrent Eye Research
Volume3
Issue number1
DOIs
StatePublished - 1984

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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