Lessons from the murine models of West Nile virus infection

Brenna McGruder, Vandana Saxena, Tian Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

West Nile virus (WNV), a mosquito-borne, single positive-stranded RNA virus, has been the leading cause of arboviral encephalitis in the U.S. and other parts of the world over the past decade. Up to 50 % of WNV convalescent patients were reported to have long-term neurological sequelae or chronic kidney diseases. However, there are neither antiviral drugs nor vaccines available for humans. The underlying mechanism of the long-term sequelae is not clearly understood either. Animal models have been an effective tool to investigate viral pathogenesis and host immunity in humans. Here, we will review several commonly used murine models of WNV infection.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages61-69
Number of pages9
Volume1435
DOIs
StatePublished - 2016
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1435
ISSN (Print)10643745

Keywords

  • Immunity
  • Infection
  • Mice
  • Pathogenesis
  • West Nile virus

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    McGruder, B., Saxena, V., & Wang, T. (2016). Lessons from the murine models of West Nile virus infection. In Methods in Molecular Biology (Vol. 1435, pp. 61-69). (Methods in Molecular Biology; Vol. 1435). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3670-0_6