Leucine for retention of lean mass on a hypocaloric diet

Jean Jitomir, Darryn S. Willoughby

    Research output: Contribution to journalReview articlepeer-review

    15 Scopus citations


    As obesity rates continue to climb, there is a pressing need for novel weight loss techniques. However, the energy-restricted diets recommended for weight loss typically result in significant amounts of lean tissue loss, in addition to the desired body fat loss. Leucine, a supported anticatabolic agent, has shown promise in research at many levels. First, leucine is known to stimulate the mammalian target of rapomycin pathway, which initiates translation and protein synthesis in muscle cells. Furthermore, leucine may help to regulate blood glucose levels by promoting gluconeogenesis. Finally, several recent studies provide evidence that leucine aids in the retention of lean mass in a hypocaloric state. The aim of this paper is to review relevant leucine research in the three areas described and assess its potential as supplement for obese individuals.

    Original languageEnglish (US)
    Pages (from-to)606-609
    Number of pages4
    JournalJournal of Medicinal Food
    Issue number4
    StatePublished - Dec 1 2008


    • Body weight
    • Branched-chain amino acids
    • Muscle
    • Nutrition
    • Obesity
    • Overweight
    • Weight loss

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics


    Dive into the research topics of 'Leucine for retention of lean mass on a hypocaloric diet'. Together they form a unique fingerprint.

    Cite this