Leucine for retention of lean mass on a hypocaloric diet

Jean Jitomir, Darryn S. Willoughby

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


As obesity rates continue to climb, there is a pressing need for novel weight loss techniques. However, the energy-restricted diets recommended for weight loss typically result in significant amounts of lean tissue loss, in addition to the desired body fat loss. Leucine, a supported anticatabolic agent, has shown promise in research at many levels. First, leucine is known to stimulate the mammalian target of rapomycin pathway, which initiates translation and protein synthesis in muscle cells. Furthermore, leucine may help to regulate blood glucose levels by promoting gluconeogenesis. Finally, several recent studies provide evidence that leucine aids in the retention of lean mass in a hypocaloric state. The aim of this paper is to review relevant leucine research in the three areas described and assess its potential as supplement for obese individuals.

Original languageEnglish (US)
Pages (from-to)606-609
Number of pages4
JournalJournal of Medicinal Food
Issue number4
StatePublished - Dec 1 2008
Externally publishedYes


  • Body weight
  • Branched-chain amino acids
  • Muscle
  • Nutrition
  • Obesity
  • Overweight
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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